Enzalutamide and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Enzalutamide and Nirmatrelvir/Ritonavir.
Enzalutamide and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Enzalutamide and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Enzalutamide lowers the levels of nirmatrelvir/ritonavir in your body by speeding up how it is processed. This can prevent the medicine from fighting the virus effectively.
FDA Label Information
Anticancer drugs apalutamide, enzalutamide ↓ nirmatrelvir/ritonavir Co-administration contraindicated due to potential loss of virologic response and possible resistance [see Contraindications (4) ].
Enzalutamide Also Interacts With
- Rifampin minor
- Digoxin minor
- Gemfibrozil minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Enzalutamide + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Enzalutamide's 4. In the major band specifically: Enzalutamide has 1; Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Enzalutamide and Nirmatrelvir/Ritonavir?
Enzalutamide lowers the levels of nirmatrelvir/ritonavir in your body by speeding up how it is processed. This can prevent the medicine from fighting the virus effectively.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Enzalutamide
SPL source-record counts only. This page's band is major · classes on file: Enzalutamide (Androgen Receptor Inhibitor); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Enzalutamide's 1.
1 major · 0 moderate · 3 minor · 4 total
Enzalutamide has no other major-band peer in this dataset besides Nirmatrelvir/Ritonavir.
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.