Enzalutamide and Rifampin Interaction
Drug interaction information between Enzalutamide and Rifampin.
Enzalutamide and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Enzalutamide and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin makes your body clear out enzalutamide faster than normal. This can lower the amount of medicine in your system and make it less effective at treating your condition.
FDA Label Information
Strong CYP3A4 Inducers The coadministration of XTANDI with rifampin (a strong CYP3A4 inducer and a moderate CYP2C8 inducer) decreases plasma concentrations of enzalutamide plus N-desmethyl enzalutamide, which may decrease the efficacy of XTANDI.
Enzalutamide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Digoxin minor
- Gemfibrozil minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Enzalutamide + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Enzalutamide's 4. In the minor band specifically: Enzalutamide has 3 (also Digoxin, Gemfibrozil); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Enzalutamide and Rifampin?
Rifampin makes your body clear out enzalutamide faster than normal. This can lower the amount of medicine in your system and make it less effective at treating your condition.
Rifampin carries more major-labeled pairs than Enzalutamide
SPL source-record counts only. This page's band is minor · classes on file: Enzalutamide (Androgen Receptor Inhibitor); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Enzalutamide's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 3 minor · 4 total
- Other minor peers for Enzalutamide
- Digoxin
- Gemfibrozil
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.