Enzalutamide and Gemfibrozil Interaction
Drug interaction information between Enzalutamide and Gemfibrozil.
Enzalutamide and Gemfibrozil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Enzalutamide and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil blocks the body from breaking down enzalutamide properly. This causes the drug to stay in your blood longer and can increase your risk of having bad side effects.
FDA Label Information
( 7.2 ) 7.1 Effect of Other Drugs on XTANDI Strong CYP2C8 Inhibitors The coadministration of XTANDI with gemfibrozil (a strong CYP2C8 inhibitor) increases plasma concentrations of enzalutamide plus N-desmethyl enzalutamide, which may increase the incidence and severity of adverse reactions of XTANDI.
Enzalutamide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Rifampin minor
- Digoxin minor
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Enzalutamide + Gemfibrozil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Enzalutamide's 4. In the minor band specifically: Enzalutamide has 3 (also Rifampin, Digoxin); Gemfibrozil has 8 (also Colchicine, Colestipol, Metformin/Pioglitazone, Montelukast).
What mechanism field is on file for Enzalutamide and Gemfibrozil?
Gemfibrozil blocks the body from breaking down enzalutamide properly. This causes the drug to stay in your blood longer and can increase your risk of having bad side effects.
Gemfibrozil carries more major-labeled pairs than Enzalutamide
SPL source-record counts only. This page's band is minor · classes on file: Enzalutamide (Androgen Receptor Inhibitor); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Enzalutamide's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 3 minor · 4 total
4 major · 8 moderate · 8 minor · 20 total
- Other minor peers for Gemfibrozil
- Colchicine
- Colestipol
- Metformin/Pioglitazone
- Montelukast
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.