Enzalutamide and Digoxin Interaction
Drug interaction information between Enzalutamide and Digoxin.
Enzalutamide and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Enzalutamide and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Enzalutamide interferes with the way labs measure digoxin in your blood, leading to test results that look higher than they really are. This is a problem with the test itself, not the actual amount of drug in your body.
FDA Label Information
7.3 Laboratory Test Interference XTANDI can interfere with certain digoxin immunoassays (e.g., Chemiluminescent Microparticle Immunoassays), resulting in falsely elevated digoxin plasma concentration results. Notify the laboratory conducting the digoxin plasma concentration assay to use an appropriate method in patients receiving XTANDI and digoxin [see Warnings and Precautions ( 5.8 )] .
Enzalutamide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Rifampin minor
- Gemfibrozil minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Enzalutamide + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Enzalutamide's 4. In the minor band specifically: Enzalutamide has 3 (also Rifampin, Gemfibrozil); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Enzalutamide and Digoxin?
Enzalutamide interferes with the way labs measure digoxin in your blood, leading to test results that look higher than they really are. This is a problem with the test itself, not the actual amount of drug in your body.
Digoxin carries more major-labeled pairs than Enzalutamide
SPL source-record counts only. This page's band is minor · classes on file: Enzalutamide (Androgen Receptor Inhibitor); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Enzalutamide's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 3 minor · 4 total
- Other minor peers for Enzalutamide
- Rifampin
- Gemfibrozil
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.