What the FDA labels say about taking them together
Digoxin and enzalutamide
Enzalutamide's FDA label of July 28, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name enzalutamide. The enzalutamide label: “Laboratory Test Interference XTANDI can interfere with certain digoxin immunoassays, resulting in falsely elevated digoxin plasma concentration results.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the enzalutamide FDA label on DailyMed (effective July 28, 2026, Astellas Pharma US, Inc.).
What does the digoxin label say about enzalutamide?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name enzalutamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the enzalutamide label say about digoxin?
Enzalutamide label, drug interactionsLaboratory Test Interference XTANDI can interfere with certain digoxin immunoassays (e.g., Chemiluminescent Microparticle Immunoassays), resulting in falsely elevated digoxin plasma concentration results.
Enzalutamide label, warnings and precautionsInterference with Immunoassay Measurement of Digoxin: XTANDI can interfere with certain digoxin immunoassays, resulting in falsely elevated digoxin plasma concentration results.
Source: FDA drug label (Xtandi), Astellas Pharma US, Inc., effective July 28, 2026 (SPL set b129fdc9-1d8e-425c-a5a9-8a2ed36dfbdf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Enzalutamide | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Prostate cancer |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once