Doxycycline Hyclate and Doxycycline Interaction
Drug interaction information between Doxycycline Hyclate and Doxycycline.
Doxycycline Hyclate and Doxycycline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Doxycycline Hyclate and Doxycycline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Certain medications can cause your body to clear doxycycline from your system much faster than usual.
FDA Label Information
Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
Doxycycline Hyclate Also Interacts With
- Tetracycline moderate
- Carbamazepine minor
- Bismuth Subsalicylate minor
- Phenytoin minor
Doxycycline Also Interacts With
- Tetracycline moderate
- Rifampin moderate
- Carbamazepine minor
- Bismuth Subsalicylate minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Doxycycline Hyclate + Doxycycline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Doxycycline has 9 labeled pairs on file vs Doxycycline Hyclate's 5. In the minor band specifically: Doxycycline Hyclate has 4 (also Carbamazepine, Bismuth Subsalicylate, Phenytoin); Doxycycline has 7 (also Carbamazepine, Bismuth Subsalicylate, Phenytoin, Ethinyl Estradiol).
What mechanism field is on file for Doxycycline Hyclate and Doxycycline?
Certain medications can cause your body to clear doxycycline from your system much faster than usual.
Doxycycline's labeled portfolio outnumbers Doxycycline Hyclate
SPL source-record counts only. This page's band is minor · classes on file: Doxycycline Hyclate (Tetracycline Antibiotic (Antimalarial)); Doxycycline (Tetracycline Antibiotic).
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Doxycycline Hyclate
- Carbamazepine
- Bismuth Subsalicylate
- Phenytoin
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Doxycycline
- Carbamazepine
- Bismuth Subsalicylate
- Phenytoin
- Ethinyl Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.