Doxazosin and Propranolol Interaction
Drug interaction information between Doxazosin and Propranolol.
Doxazosin and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Doxazosin and Propranolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs lower blood pressure, which can cause a sudden drop in pressure when you stand up. This can make you feel dizzy or faint.
What To Do
Stand up slowly from a sitting or lying position to avoid falling. Your doctor may need to adjust your medication doses.
FDA Label Information
Postural hypotension has been reported in patients taking both beta-blockers and terazosin or doxazosin.
Propranolol Also Interacts With
- Clonidine minor
- Diltiazem minor
- Warfarin minor
- Verapamil minor
- Haloperidol minor
Frequently Asked Questions
Can I take Doxazosin and Propranolol together?
This is a minor interaction. Stand up slowly from a sitting or lying position to avoid falling. Your doctor may need to adjust your medication doses.
How serious is the interaction between Doxazosin and Propranolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Doxazosin and Propranolol interact?
Both drugs lower blood pressure, which can cause a sudden drop in pressure when you stand up. This can make you feel dizzy or faint.
Understanding the Doxazosin and Propranolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Doxazosin belongs to the Alpha-1 Adrenergic Blocker class and Propranolol belongs to the Non-Selective Beta-Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs lower blood pressure, which can cause a sudden drop in pressure when you stand up. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Doxazosin has 2 total documented interactions on file in this dataset, and Propranolol has 44. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Stand up slowly from a sitting or lying position to avoid falling. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Doxazosin or Propranolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.