Donepezil and Ramelteon Interaction
Drug interaction information between Donepezil and Ramelteon.
Donepezil and Ramelteon have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Donepezil and Ramelteon. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Donepezil makes it harder for your body to get rid of ramelteon, leading to higher levels of the drug in your blood.
FDA Label Information
( 7.1 ) Donepezil: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with donepezil. Donepezil The AUC 0-inf and C max of ramelteon increased by approximately 100% and 87%, respectively upon coadministration of donepezil with ramelteon. Patients should be closely monitored when ramelteon is coadministered with donepezil [see Clinical Pharmacology (12.5) ] .
Ramelteon Also Interacts With
- Ketoconazole moderate
- Fluconazole moderate
- Doxepin minor
- Rifampin minor
- Fluvoxamine minor
Frequently Asked Questions
What SPL severity band is on file for Donepezil + Ramelteon?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ramelteon has 7 labeled pairs on file vs Donepezil's 2. In the minor band specifically: Donepezil has 2 (also Bethanechol); Ramelteon has 5 (also Doxepin, Rifampin, Fluvoxamine, Itraconazole).
What mechanism field is on file for Donepezil and Ramelteon?
Donepezil makes it harder for your body to get rid of ramelteon, leading to higher levels of the drug in your blood.
Ramelteon's labeled portfolio outnumbers Donepezil
SPL source-record counts only. This page's band is minor · classes on file: Donepezil (Acetylcholinesterase Inhibitor); Ramelteon (Melatonin Receptor Agonist).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Ramelteon
- Doxepin
- Rifampin
- Fluvoxamine
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.