Donepezil and Bethanechol Interaction
Drug interaction information between Donepezil and Bethanechol.
Donepezil and Bethanechol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Donepezil and Bethanechol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs work in a similar way to increase a specific chemical in the body. Taking them together can make this effect much stronger than intended.
FDA Label Information
7.2 Use with Cholinomimetics and Other Cholinesterase Inhibitors A synergistic effect may be expected when cholinesterase inhibitors are given concurrently with succinylcholine, similar neuromuscular blocking agents, or cholinergic agonists such as bethanechol.
Frequently Asked Questions
What SPL severity band is on file for Donepezil + Bethanechol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Donepezil and Bethanechol tie at 2 labeled pairs each. minor-band counts: Donepezil 2 alongside Ramelteon; Bethanechol 2 alongside Galantamine.
What mechanism field is on file for Donepezil and Bethanechol?
Both drugs work in a similar way to increase a specific chemical in the body. Taking them together can make this effect much stronger than intended.
Donepezil and Bethanechol · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Donepezil (Acetylcholinesterase Inhibitor); Bethanechol (Cholinergic Agonist (Urinary Retention)).
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.