Benzoyl Peroxide and Adapalene Interaction
Drug interaction information between Benzoyl Peroxide and Adapalene.
Benzoyl Peroxide and Adapalene have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Benzoyl Peroxide and Adapalene. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There are no known studies showing that these two skin treatments interfere with each other.
FDA Label Information
No formal drug-drug interaction studies were conducted with adapalene and benzoyl peroxide gel 0.1% / 2.5%.
Frequently Asked Questions
What SPL severity band is on file for Benzoyl Peroxide + Adapalene?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Benzoyl Peroxide has 2 labeled pairs on file vs Adapalene's 1. In the minor band specifically: Benzoyl Peroxide has 2 (also Dapsone Topical); Adapalene has 1.
What mechanism field is on file for Benzoyl Peroxide and Adapalene?
There are no known studies showing that these two skin treatments interfere with each other.
Benzoyl Peroxide's labeled portfolio outnumbers Adapalene
SPL source-record counts only. This page's band is minor · classes on file: Benzoyl Peroxide (Antimicrobial (Topical)); Adapalene (Retinoid (Topical)).
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Benzoyl Peroxide
- Dapsone Topical
0 major · 0 moderate · 1 minor · 1 total
Adapalene has no other minor-band peer in this dataset besides Benzoyl Peroxide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.