Atenolol · more major-labeled pairs than Clonidine
SPL labels Clonidine + Atenolol as minor; Clonidine 25 / Atenolol 12 in that band.
Mechanism on file: Stopping clonidine can cause a sudden, dangerous rise in blood pressure, and taking a beta-blocker can make this reaction even worse.
FDA SPL severity: Minor
Clonidine + Atenolol · SPL mechanism field
Stopping clonidine can cause a sudden, dangerous rise in blood pressure, and taking a beta-blocker can make this reaction even worse.
Minor band excerpt · Clonidine with Atenolol
Beta-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. If the two drugs are coadministered, the beta-blocker should be withdrawn several days before the gradual withdrawal of clonidine. If replacing clonidine by beta-blocker therapy, the introduction of beta-blockers should be delayed for several days after clonidine administration has stopped.
Clonidine · 29 SPL pairs (broader portfolio than Atenolol)
- Amiodarone minor
- Amitriptyline minor
- Brimonidine Ophthalmic minor
- Brimonidine/Timolol minor
Atenolol · 2 major-labeled pairs (vs Clonidine's 0)
- Amiodarone minor
- Dutasteride minor
- Dutasteride/Tamsulosin minor
- Epinephrine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.