Clonidine · larger labeled portfolio than Brimonidine/Timolol
SPL labels Clonidine + Brimonidine/Timolol as minor; Clonidine 25 / Brimonidine/Timolol 2 in that band.
Mechanism on file: Both drugs work in a similar way to lower blood pressure. Taking them together can cause an additive effect, which might make your blood pressure drop too low.
FDA SPL severity: Minor
Brimonidine/Timolol
Full Brimonidine/Timolol label recordAlpha-2 Agonist / Beta-Blocker Combination
Clonidine + Brimonidine/Timolol · SPL mechanism field
Both drugs work in a similar way to lower blood pressure. Taking them together can cause an additive effect, which might make your blood pressure drop too low.
Minor band excerpt · Clonidine with Brimonidine/Timolol
( 7.7 ) Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine. 7.8 Tricyclic Antidepressants Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.
Clonidine · 29 SPL pairs (broader portfolio than Brimonidine/Timolol)
- Amiodarone minor
- Amitriptyline minor
- Atenolol minor
- Brimonidine Ophthalmic minor
Brimonidine/Timolol · 2 minor + 2 total pairs
- Timolol minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.