Clarithromycin · more major-labeled pairs than Colchicine
SPL labels Clarithromycin + Colchicine as major; Clarithromycin 16 / Colchicine 4 in that band.
Mechanism on file: Clarithromycin blocks the enzymes and transporters that remove colchicine from your body, which can lead to toxic levels of the drug.
FDA SPL severity: Major
Clarithromycin + Colchicine · SPL mechanism field
Clarithromycin blocks the enzymes and transporters that remove colchicine from your body, which can lead to toxic levels of the drug.
Major band excerpt · Clarithromycin with Colchicine
Fluconazole No Dose Adjustment Fluconazole: [see Pharmacokinetics ( 12.3 )] Anti-Gout Agents: Colchicine (in patients with renal or hepatic impairment) Contraindicated Colchicine: Colchicine is a substrate for both CYP3A and the efflux transporter, P-glycoprotein (Pgp). The dose of colchicine should be reduced when co-administered with clarithromycin in patients with normal renal and hepatic function [see Contraindications ( 4.4 ) and Warnings and Precautions ( 5.4 )] . Colchicine (in patients with normal renal and hepatic function) Use With Caution Antipsychotics: Pimozide Contraindicated...
Clarithromycin · 16 major-labeled pairs (vs Colchicine's 4)
- Atorvastatin major
- Cyclosporine major
- Dronedarone major
- Fluconazole major
Colchicine · 4 major + 28 total pairs
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.