Clarithromycin · more major-labeled pairs than Dronedarone
SPL labels Clarithromycin + Dronedarone as major; Clarithromycin 16 / Dronedarone 9 in that band.
Mechanism on file: Clarithromycin blocks the process your body uses to clear dronedarone. This leads to a significant increase in the amount of dronedarone in your blood.
FDA SPL severity: Major
Clarithromycin + Dronedarone · SPL mechanism field
Clarithromycin blocks the process your body uses to clear dronedarone. This leads to a significant increase in the amount of dronedarone in your blood.
Major band excerpt · Clarithromycin with Dronedarone
7.2 Effects of Other Drugs on Dronedarone Ketoconazole and Other Potent CYP3A Inhibitors Concomitant use of ketoconazole as well as other potent CYP3A inhibitors such as itraconazole, voriconazole, ritonavir, clarithromycin, and nefazodone is contraindicated because exposure to dronedarone is significantly increased [see Contraindications (4) , Clinical Pharmacology (12.3) ] .
Clarithromycin · 16 major-labeled pairs (vs Dronedarone's 9)
- Atorvastatin major
- Colchicine major
- Cyclosporine major
- Fluconazole major
Dronedarone · 9 major + 22 total pairs
- Darunavir major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Itraconazole major
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.