Desmopressin and Lamotrigine Interaction
Drug interaction information between Desmopressin and Lamotrigine.
Desmopressin and Lamotrigine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Desmopressin and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking lamotrigine with desmopressin can increase the risk of your body holding onto too much water and lowering your salt levels.
FDA Label Information
tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine and carbamazepine) should be performed with caution.
Desmopressin Also Interacts With
- Carbamazepine moderate
- Chlorpromazine moderate
Lamotrigine Also Interacts With
- Dofetilide moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Desmopressin + Lamotrigine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Desmopressin's 3. In the moderate band specifically: Desmopressin has 3 (also Carbamazepine, Chlorpromazine); Lamotrigine has 2 (also Dofetilide).
What mechanism field is on file for Desmopressin and Lamotrigine?
Taking lamotrigine with desmopressin can increase the risk of your body holding onto too much water and lowering your salt levels.
Lamotrigine's labeled portfolio outnumbers Desmopressin
SPL source-record counts only. This page's band is moderate · classes on file: Desmopressin (Vasopressin Analog); Lamotrigine (Anticonvulsant).
0 major · 3 moderate · 0 minor · 3 total
- Other moderate peers for Desmopressin
- Carbamazepine
- Chlorpromazine
0 major · 2 moderate · 22 minor · 24 total
- Other moderate peers for Lamotrigine
- Dofetilide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.