Buspirone and Diphenoxylate/Atropine Interaction
Drug interaction information between Buspirone and Diphenoxylate/Atropine.
Buspirone and Diphenoxylate/Atropine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Buspirone and Diphenoxylate/Atropine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can slow down the central nervous system, and taking them together can make these drowsy effects much stronger.
FDA Label Information
Other Drugs that Cause CNS Depression The concurrent use of Lomotil with other drugs that cause CNS depression (e.g., barbiturates, benzodiazepines, opioids, buspirone, antihistamines, muscle relaxants), may potentiate the effects of Lomotil (see WARNINGS ).
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Buspirone + Diphenoxylate/Atropine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buspirone has 17 labeled pairs on file vs Diphenoxylate/Atropine's 1. In the minor band specifically: Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem); Diphenoxylate/Atropine has 1.
What mechanism field is on file for Buspirone and Diphenoxylate/Atropine?
Both of these medicines can slow down the central nervous system, and taking them together can make these drowsy effects much stronger.
Buspirone's labeled portfolio outnumbers Diphenoxylate/Atropine
SPL source-record counts only. This page's band is minor · classes on file: Buspirone (Azapirone Anxiolytic); Diphenoxylate/Atropine (Antidiarrheal Combination).
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
0 major · 0 moderate · 1 minor · 1 total
Diphenoxylate/Atropine has no other minor-band peer in this dataset besides Buspirone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.