buspirone vs diphenoxylate/atropine
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Side-by-side comparison of buspirone and diphenoxylate/atropine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Other Drugs that Cause CNS Depression The concurrent use of Lomotil with other drugs that cause CNS depression (e.g., barbiturates, benzodiazepines, opioids, buspirone, antihistamines, muscle relaxants), may potentiate the effects of Lomotil (see WARNINGS ).
BuSpar
Lomotil
Buspirone is a medicine that can help manage anxiety disorders. It can also provide short-term relief from anxiety symptoms.
Lomotil is a drug that helps manage diarrhea. It contains two medicines, diphenoxylate and atropine, to slow down your bowels.
Buspirone is used to manage anxiety disorders. It can also help relieve anxiety symptoms for a short time. This medicine is often used for Generalized Anxiety Disorder (GAD), which involves constant worry and tension.
Lomotil is used to treat diarrhea in people 13 years and older. It is used along with other treatments. Make sure you drink enough fluids and get electrolytes while taking Lomotil.
Buspirone affects certain chemicals in your brain that may be unbalanced. This helps to reduce anxiety. It is different from other anxiety medicines like benzodiazepines.
Lomotil works by slowing down the movement of your intestines. Diphenoxylate reduces bowel contractions. Atropine is added to discourage people from taking too much of this medicine.
- • Dizziness
- • Nausea
- • Headache
- • Nervousness
- • Lightheadedness
- • Numbness in your arms and legs
- • Feeling of well-being
- • Depression
- • Feeling tired or weak
- • Confusion
- Fatigue 759
- Nausea 744
- Headache 675
- Anxiety 636
- Pain 541
No adverse event reports.
You should not take buspirone if you are taking a monoamine oxidase inhibitor (MAOI) antidepressant or have taken one in the past 14 days. Do not start buspirone if you are being treated with linezolid or intravenous methylene blue because of the risk of serotonin syndrome. Serotonin syndrome is a very serious condition.
Lomotil can cause serious side effects, including breathing problems and nervous system issues. Dehydration and electrolyte imbalance can also occur. If you have an infection causing your diarrhea, Lomotil can make it worse. Do not use if you are under 6 years old.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if buspirone will harm your unborn baby. Buspirone may pass into breast milk.
It is not known if Lomotil can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if Lomotil passes into breast milk, so talk to your doctor if you are breastfeeding.
How to Read This buspirone vs diphenoxylate/atropine Comparison
buspirone is classified in the Azapirone Anxiolytic drug class, while diphenoxylate/atropine sits within the Antidiarrheal Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, buspirone has 3,355 submissions while diphenoxylate/atropine has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these medicines can slow down the central nervous system, and taking them together can make these drowsy effects much stronger.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for buspirone or diphenoxylate/atropine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.