Codeine · larger labeled portfolio than Butorphanol
SPL labels Codeine + Butorphanol as minor; Codeine 27 / Butorphanol 10 in that band.
Mechanism on file: Butorphanol can block the pain-relieving effects of codeine and may cause sudden, uncomfortable withdrawal symptoms.
FDA SPL severity: Minor
Codeine + Butorphanol · SPL mechanism field
Butorphanol can block the pain-relieving effects of codeine and may cause sudden, uncomfortable withdrawal symptoms.
Minor band excerpt · Codeine with Butorphanol
Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of acetaminophen and codeine phosphate tablets and/or precipitate withdrawal symptoms.
Codeine · 27 SPL pairs (broader portfolio than Butorphanol)
- Acetaminophen minor
- Alprazolam minor
- Buprenorphine minor
- Bupropion minor
Butorphanol · 10 minor + 11 total pairs
- Acetaminophen/Oxycodone minor
- Buprenorphine (Pain) minor
- Fentanyl minor
- Hydromorphone minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.