Benzoyl Peroxide and Dapsone Topical Interaction
Drug interaction information between Benzoyl Peroxide and Dapsone Topical.
Benzoyl Peroxide and Dapsone Topical have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Benzoyl Peroxide and Dapsone Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two skin treatments can react with each other on your skin to cause a temporary yellow or orange stain.
FDA Label Information
Topical benzoyl peroxide used at the same time as ACZONE Gel, 7.5% may result in temporary local yellow or orange skin discoloration ( 7.2 ). 7.2 Topical Benzoyl Peroxide Topical application of dapsone gel followed by benzoyl peroxide in patients with acne vulgaris may result in a temporary local yellow or orange discoloration of the skin and facial hair.
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Chloroquine moderate
- Nitroglycerin moderate
- Phenytoin moderate
Frequently Asked Questions
What SPL severity band is on file for Benzoyl Peroxide + Dapsone Topical?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapsone Topical has 10 labeled pairs on file vs Benzoyl Peroxide's 2. In the minor band specifically: Benzoyl Peroxide has 2 (also Adapalene); Dapsone Topical has 4 (also Folic Acid, Trimethoprim, Rifampin).
What mechanism field is on file for Benzoyl Peroxide and Dapsone Topical?
These two skin treatments can react with each other on your skin to cause a temporary yellow or orange stain.
Dapsone Topical's labeled portfolio outnumbers Benzoyl Peroxide
SPL source-record counts only. This page's band is minor · classes on file: Benzoyl Peroxide (Antimicrobial (Topical)); Dapsone Topical (Topical Anti-Inflammatory).
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Benzoyl Peroxide
- Adapalene
0 major · 6 moderate · 4 minor · 10 total
- Other minor peers for Dapsone Topical
- Folic Acid
- Trimethoprim
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.