amoxicillin/clavulanate vs estradiol
Side-by-side comparison of amoxicillin/clavulanate and estradiol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
Recommendation: Consult your healthcare provider to see if you need to monitor your hormone levels or use additional birth control.
Augmentin
Estrace, Vivelle-Dot
Augmentin is a combination of two medicines, amoxicillin and clavulanate. It is an antibiotic that fights bacteria in your body.
Iclevia is a birth control pill. It contains two hormones, a progestin and an estrogen, that work together to prevent pregnancy.
Augmentin treats infections caused by bacteria. It is used for infections such as lower respiratory infections, ear infections, sinus infections, skin infections, and urinary tract infections. This medicine will not work for viral infections, such as colds or the flu.
Iclevia is used by women who can get pregnant to prevent pregnancy. It contains two types of hormones. These hormones stop you from releasing an egg and also change the lining of your uterus, which prevents pregnancy.
Amoxicillin kills bacteria. Clavulanate helps amoxicillin work better by preventing bacteria from breaking down amoxicillin. This combination helps to fight a wider range of bacteria.
Iclevia contains two hormones: levonorgestrel (a progestin) and ethinyl estradiol (an estrogen). These hormones prevent pregnancy by stopping ovulation (the release of an egg from the ovary). They also change the lining of the uterus to prevent a fertilized egg from implanting.
- • Diarrhea or loose stools
- • Nausea
- • Skin rashes
- • Hives
- • Vomiting
- • Headache
- • Heavy menstrual bleeding
- • Nausea
- • Painful periods
- • Acne
- Long-term kidney disease 4,661
- Sudden kidney damage 4,200
- Diarrhea 4,083
- Drug allergy 3,744
- Feeling sick to your stomach 3,700
- The product did not stick properly 5,172
- Headache 5,035
- Nausea 4,752
- Tiredness 4,511
- Pain 3,478
Augmentin can cause serious allergic reactions, including fatal ones. Stop taking Augmentin and get medical help right away if you have any signs of an allergic reaction. Augmentin can also cause severe skin reactions. Tell your doctor if you develop a rash. This drug can also cause liver problems and severe diarrhea.
Cigarette smoking increases your risk of serious heart problems from birth control pills. This risk is higher if you are over 35 and smoke more cigarettes. You should not take Iclevia if you are over 35 and smoke.
Animal studies show Augmentin may be safe during pregnancy, but there are no good studies in pregnant women. Talk to your doctor if you are pregnant or plan to become pregnant. Amoxicillin passes into breast milk and may cause problems for the baby, so talk to your doctor if you are breastfeeding.
Do not use Iclevia if you are pregnant. If you become pregnant while taking Iclevia, stop taking it right away. Iclevia can reduce milk production, so you may want to use a different birth control method while breastfeeding.
How to Read This amoxicillin/clavulanate vs estradiol Comparison
amoxicillin/clavulanate is classified in the Penicillin / Beta-Lactamase Inhibitor Combination drug class, while estradiol sits within the Estrogen Hormone class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amoxicillin/clavulanate has 20,388 submissions while estradiol has 22,948. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this medication can cause a temporary drop in the levels of estrogen hormones found in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amoxicillin/clavulanate and estradiol - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.