Amitriptyline · more major-labeled pairs than Clonidine
SPL labels Amitriptyline + Clonidine as minor; Amitriptyline 20 / Clonidine 25 in that band.
Mechanism on file: These drugs may work together to cause damage to the clear front part of the eye.
FDA SPL severity: Minor
Amitriptyline + Clonidine · SPL mechanism field
These drugs may work together to cause damage to the clear front part of the eye.
Minor band excerpt · Amitriptyline with Clonidine
Amitriptyline in combination with clonidine enhances the manifestation of corneal lesions in rats (see Toxicology ). In combination with amitriptyline, clonidine hydrochloride administration led to the development of corneal lesions in rats within 5 days.
Amitriptyline · 1 major-labeled pairs (vs Clonidine's 0)
- Carbamazepine minor
- Cimetidine minor
- Darunavir minor
- Disulfiram minor
Clonidine · 29 SPL pairs (broader portfolio than Amitriptyline)
- Amiodarone minor
- Atenolol minor
- Brimonidine Ophthalmic minor
- Brimonidine/Timolol minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.