Carbamazepine · more major-labeled pairs than Amitriptyline
SPL labels Amitriptyline + Carbamazepine as minor; Amitriptyline 20 / Carbamazepine 110 in that band.
Mechanism on file: Carbamazepine speeds up the way your body clears amitriptyline, which can make the antidepressant less effective.
FDA SPL severity: Minor
Amitriptyline + Carbamazepine · SPL mechanism field
Carbamazepine speeds up the way your body clears amitriptyline, which can make the antidepressant less effective.
Minor band excerpt · Amitriptyline with Carbamazepine
In addition, carbamazepine causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam,...
Amitriptyline · 20 minor + 21 total pairs
- Cimetidine minor
- Clonidine minor
- Darunavir minor
- Disulfiram minor
Carbamazepine · 3 major-labeled pairs (vs Amitriptyline's 1)
- Acetaminophen minor
- Acetaminophen/Oxycodone minor
- Albendazole minor
- Alprazolam minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.