Cimetidine · more major-labeled pairs than Amitriptyline
SPL labels Amitriptyline + Cimetidine as minor; Amitriptyline 20 / Cimetidine 63 in that band.
Mechanism on file: Cimetidine slows down the liver's ability to process amitriptyline, which can cause the drug to build up in your body. This increase in drug levels can lead to more side effects.
FDA SPL severity: Minor
Amitriptyline + Cimetidine · SPL mechanism field
Cimetidine slows down the liver's ability to process amitriptyline, which can cause the drug to build up in your body. This increase in drug levels can lead to more side effects.
Minor band excerpt · Amitriptyline with Cimetidine
The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants, thereby delaying elimination and increasing steady-state concentrations of these drugs. Clinically significant effects have been reported with the tricyclic antidepressants when used concomitantly with cimetidine.
Amitriptyline · 20 minor + 21 total pairs
- Carbamazepine minor
- Clonidine minor
- Darunavir minor
- Disulfiram minor
Cimetidine · 4 major-labeled pairs (vs Amitriptyline's 1)
- Albendazole minor
- Alogliptin minor
- Alosetron minor
- Alprazolam minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.