probenecid
Brand names: Benemid
Orlynvah is a drug that combines two medicines to treat uncomplicated urinary tract infections (UTIs) in adult women. It contains an antibacterial to kill bacteria and another medicine to help the antibacterial work better.
Drug Pricing (NADAC)
Generic Price
$0.87/unit
Generic Available
Yes (6 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Orlynvah treats uncomplicated urinary tract infections (UTIs) in adult women.
Common side effects
Diarrhea, Nausea, Yeast infection of the vagina
Key warnings
You should not take this medicine if you are allergic to any of its ingredients or to other beta-lactam antibiotics.
How It Works
Orlynvah contains sulopenem etzadroxil, which is an antibacterial that kills bacteria. It also contains probenecid, which helps the sulopenem etzadroxil stay in your body longer. This allows the antibacterial to work better against the bacteria causing the UTI.
How to Take It
Take one Orlynvah tablet twice a day for 5 days. It is best to take it with food. Swallow the tablet whole with a full glass of water. If you miss a dose, take it as soon as you remember, but do not take two doses at once.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if Orlynvah will harm your unborn baby. Probenecid, one of the drugs in Orlynvah, does cross the placenta.
Missed Dose
If you miss a dose of Orlynvah, take it as soon as you remember. Do not take two doses at the same time to make up for the missed dose.
Storage
Store Orlynvah tablets at room temperature, between 68°F and 77°F.
Side Effects (from patient reports)
Based on 513 FDA adverse event reports.
FDA Adverse Event Report Analysis
Detailed analysis of 1,152 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
1,152
Death-Related Reports
163
Hospitalization Reports
396
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DIARRHOEA | 76 |
| 2 | DRUG INEFFECTIVE | 66 |
| 3 | OFF LABEL USE | 58 |
| 4 | DYSPNOEA | 52 |
| 5 | ADENOVIRUS INFECTION | 47 |
| 6 | ASTHENIA | 47 |
| 7 | FATIGUE | 46 |
| 8 | NAUSEA | 41 |
| 9 | PAIN | 41 |
| 10 | DIZZINESS | 39 |
| 11 | PNEUMONIA | 39 |
| 12 | RENAL FAILURE | 37 |
| 13 | ACUTE KIDNEY INJURY | 36 |
| 14 | VOMITING | 36 |
| 15 | DEATH | 35 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
You should not take this medicine if you are allergic to any of its ingredients or to other beta-lactam antibiotics. You should not take this medicine if you have uric acid kidney stones. Do not take this medicine with ketorolac tromethamine.
Known Drug Interactions
Established and Other Potentially Clinically Significant Drug Interactions Concomitant Drug/Drug Class Effect on Drug Concentration Recommendation Ketorolac tromethamine ↑ ketorolac tromethamine Contraindicated Ketoprofen ↑ ketoprofen Concomitant use is not recommended.
Mechanism: Probenecid slows down the body's ability to clear ketorolac, which leads to much higher and potentially unsafe levels of the drug in your system.
What to do: These two medicines should not be used together.
7.8 Probenecid and Cimetidine No significant effect of probenecid or cimetidine on the Cmax of levofloxacin was observed in a clinical study involving healthy volunteers. The AUC and t 1/2 of levofloxacin were higher while CL/F and CLR were lower during concomitant treatment of levofloxacin with probenecid or cimetidine compared to levofloxacin alone. However, these changes do not warrant dosage adjustment for levofloxacin when probenecid or cimetidine is co-administered.
Mechanism: Probenecid slows down the kidneys' ability to remove levofloxacin, which keeps the antibiotic in your system for a longer time.
What to do: No dose changes are usually needed, but your doctor will monitor your progress.
7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.
Mechanism: Probenecid blocks the kidneys from removing amoxicillin from the blood. This causes the antibiotic to stay in your body longer and reach higher levels than normal.
What to do: This combination is not recommended, and you should talk to your doctor about using a different treatment plan.
7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.
Mechanism: Probenecid slows down the kidneys from clearing amoxicillin out of your system, which can lead to higher levels of the drug in your body. It does not affect how the other part of the medicine, clavulanic acid, is removed.
What to do: This combination is not recommended by the manufacturer. Talk to your doctor about alternative treatments or necessary adjustments to your prescription.
7 DRUG INTERACTIONS 7.1 Probenecid In vitro , avibactam is a substrate of OAT1 and OAT3 transporters which might contribute to the active uptake from the blood compartment, and thereby its excretion. As a potent OAT inhibitor, probenecid inhibits OAT uptake of avibactam by 56% to 70% in vitro and, therefore, has the potential to decrease the elimination of avibactam when co-administered. Because a clinical interaction study of AVYCAZ or avibactam alone with probenecid has not been conducted, co-administration of AVYCAZ with probenecid is not recommended [ see Clinical Pharmacology ( 12.3 ) ] .
Mechanism: Probenecid blocks the body's ability to move the antibiotic out of the blood and into the urine. This causes the antibiotic levels to stay too high for too long.
What to do: This combination is not recommended. Talk to your doctor about using a different medication.
Common Questions
What if I have a history of allergies to penicillin?
Can I take Orlynvah if I have kidney problems?
What should I do if I get diarrhea while taking Orlynvah?
Can Orlynvah interact with other medications I am taking?
How long should I take Orlynvah?
What if my symptoms don't improve after taking Orlynvah?
Can I drink alcohol while taking Orlynvah?
What are the ingredients in Orlynvah?
How should I dispose of unused Orlynvah?
Is there a generic version of Orlynvah available?
What are the common side effects of probenecid?
Does probenecid interact with other medications?
What drug class is probenecid?
Is probenecid safe during pregnancy?
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What the FDA Data Shows for probenecid
The FDA label for probenecid (sold under brand names such as Benemid) classifies it as a prescription-only medication in the Uricosuric Agent class. Orlynvah treats uncomplicated urinary tract infections (UTIs) in adult women. Official labeling lists 5 commonly reported side effects, including Diarrhea, Nausea, Yeast infection of the vagina.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 513 voluntary reports. The database also lists 37 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.87.
Report counts do not establish causation — a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice — always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: December 6, 2025
Read our methodology — how this data is sourced, computed, and verified.
All federal data sources used on this page
- FDA Orange Book — approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed — NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) — post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm — standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files — federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database — current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages