probenecid Side Effects
Also known as: Benemid
Analysis of 1,152 adverse event reports submitted to the FDA from 2004 to 2025.
Total Reports
1,152
Death-Related
163
14.1% of reports
Hospitalizations
396
34.4% of reports
Top Indication
Product Used For Unknown Indication
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 163 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| DEATH | 35 |
| ADENOVIRUS INFECTION | 17 |
| PNEUMONIA | 15 |
| RESPIRATORY FAILURE | 15 |
| DIARRHOEA | 12 |
| COMPLETED SUICIDE | 11 |
| HYPOTENSION | 11 |
| MULTIPLE ORGAN DYSFUNCTION SYNDROME | 11 |
| OFF LABEL USE | 11 |
| PYREXIA | 11 |
| RENAL FAILURE | 11 |
| SEPSIS | 10 |
| CARDIAC FAILURE CONGESTIVE | 9 |
| CYSTITIS HAEMORRHAGIC | 9 |
| PLEURAL EFFUSION | 9 |
| VOMITING | 9 |
| WEIGHT DECREASED | 9 |
| ABDOMINAL PAIN | 8 |
| ASTHENIA | 8 |
| CARDIAC ARREST | 8 |
Reactions in Hospitalization Reports
Top reactions in 396 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| DYSPNOEA | 31 |
| ACUTE KIDNEY INJURY | 29 |
| DIARRHOEA | 28 |
| PNEUMONIA | 28 |
| ASTHENIA | 24 |
| GASTROINTESTINAL HAEMORRHAGE | 19 |
| PYREXIA | 19 |
| ADENOVIRUS INFECTION | 18 |
| ANAEMIA | 18 |
| COUGH | 18 |
| RENAL FAILURE | 18 |
| WEIGHT DECREASED | 18 |
| PANCYTOPENIA | 17 |
| RENAL FAILURE ACUTE | 17 |
| MYOCARDIAL INFARCTION | 16 |
| CARDIAC FAILURE CONGESTIVE | 15 |
| CYSTITIS HAEMORRHAGIC | 15 |
| HYPOTENSION | 15 |
| SEPSIS | 15 |
| DEHYDRATION | 14 |
Nearby — Related Medications
What the FAERS Data Reveals About probenecid Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 1,152 voluntary reports linked to probenecid and its brand equivalents (Benemid), spanning 2004 through 2025. Of those, 163 (14.1%) listed death as an outcome and 396 (34.4%) involved hospitalization. The most common indication reported alongside adverse events was Product Used For Unknown Indication.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 32% were female and 68% male; age distribution skews toward 45-64, with 243 reports in that bracket. The single most reported reaction is diarrhoea with 76 submissions, followed by drug ineffective and off label use.
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice — speak with a licensed clinician about any side-effect concerns.
Read our methodology — how this data is sourced, computed, and verified.