LOW-VOLUME · SEX-BALANCED
probenecid Side Effects
probenecid (also sold as Benemid) is a LOW-VOLUME FAERS extract #485 of 524 by FAERS report count. Still opens on SEX-BALANCED: 32% of sex-coded reports are female (340 F / 729 M).
Data updated 2026-05-15
- 1,152
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
probenecid reporting skew - 32% of sex-coded reports are female (340 F / 729 M). Volume band LOW-VOLUME #485 of 524 by FAERS report count; caseload SIGNAL.
Thinner FAERS extract for probenecid (Benemid) (1,152 reports #485 of 524 by FAERS report count). 32% of sex-coded reports are female (340 F / 729 M). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2004–2025). Stamps SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
DIARRHOEA leads 76 of 1,152 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (243 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (163 reports, 14.1%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 35 |
| ADENOVIRUS INFECTION | 17 |
| PNEUMONIA | 15 |
| RESPIRATORY FAILURE | 15 |
| DIARRHOEA | 12 |
| COMPLETED SUICIDE | 11 |
| HYPOTENSION | 11 |
| MULTIPLE ORGAN DYSFUNCTION SYNDROME | 11 |
| PYREXIA | 11 |
| RENAL FAILURE | 11 |
| SEPSIS | 10 |
| CARDIAC FAILURE CONGESTIVE | 9 |
| CYSTITIS HAEMORRHAGIC | 9 |
| PLEURAL EFFUSION | 9 |
| VOMITING | 9 |
| WEIGHT DECREASED | 9 |
| ABDOMINAL PAIN | 8 |
| ASTHENIA | 8 |
| CARDIAC ARREST | 8 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (396, 34.4% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| DYSPNOEA | 31 |
| ACUTE KIDNEY INJURY | 29 |
| DIARRHOEA | 28 |
| PNEUMONIA | 28 |
| ASTHENIA | 24 |
| GASTROINTESTINAL HAEMORRHAGE | 19 |
| PYREXIA | 19 |
| ADENOVIRUS INFECTION | 18 |
| ANAEMIA | 18 |
| COUGH | 18 |
| RENAL FAILURE | 18 |
| WEIGHT DECREASED | 18 |
| PANCYTOPENIA | 17 |
| RENAL FAILURE ACUTE | 17 |
| MYOCARDIAL INFARCTION | 16 |
| CARDIAC FAILURE CONGESTIVE | 15 |
| CYSTITIS HAEMORRHAGIC | 15 |
| HYPOTENSION | 15 |
| SEPSIS | 15 |
| DEHYDRATION | 14 |
How to read probenecid FAERS figures (SIGNAL · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 1,152 voluntary reports linked to probenecid (Benemid), 2004-2025. Death is listed on 163 (14.1%). Hospitalization appears on 396 (34.4%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and SEX-BALANCED skew still differ by drug; not a complete safety profile.
Read with probenecid
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 1,132 FAERS cases (Δ 20 lighter vs probenecid); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 1,191 FAERS cases (Δ 39 heavier vs probenecid); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 1,205 FAERS cases (Δ 53 heavier vs probenecid); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 1,220 FAERS cases (Δ 68 heavier vs probenecid); DEATH-MARKED · HOSP-HEAVY · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 48.0 pp vs probenecid's DEATH-HEAVY): CASELOAD · HOSP-MID.
probenecid stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload SIGNAL and the label guide.