What the label lists and what reports show

Probenecid side effects

Probenecid's FDA label lists its adverse reactions in its own words. FAERS holds 1,173 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is diarrhoea (76 reports).

Generic listed

Check it at the source: the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.); the FDA FAERS public dashboard.

What does the label list?

From the label: adverse reactions
The following adverse reactions have been observed and within each category are listed in order of decreasing severity. Central Nervous System: headache, dizziness. Metabolic: precipitation of acute gouty arthritis. Gastrointestinal: hepatic necrosis, vomiting, nausea, anorexia, sore gums. Genitourinary: nephrotic syndrome, uric acid stones with or without hematuria, renal colic, costovertebral pain, urinary frequency. Hypersensitivity: anaphylaxis, fever, urticaria, pruritus. Hematologic: aplastic anemia, leukopenia, hemolytic anemia which in some patients could be related to genetic deficiency of glucose -6- phosphate dehydrogenase in red blood cells, anemia. Integumentary: dermatitis, alopecia, flushing.

Source: FDA drug label, Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed

What do FAERS reports show?

1,173 reports list probenecid among the medicines taken, each a report of something that happened, not proof the medicine caused it; 167 are coded as a death and 409 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 22 reactions below, 4 are named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.

Reports received each year

The 25 most reported reactions

Diarrhoea76
Drug Ineffective (a use or a product term, not a reaction)69
Off Label Use (a use or a product term, not a reaction)63
Dyspnoea52
Adenovirus Infection47
Asthenia47
Fatigue47
Nausea (named in the label)42
Acute Kidney Injury41
Pain41
Dizziness (named in the label)40
Pneumonia39
Renal Failure38
Vomiting (named in the label)36
Death (an outcome recorded in the report)35
Pyrexia34
Headache (named in the label)33
Abdominal Pain30
Weight Decreased29
Arthralgia28
Cough28
Pain In Extremity28
Anxiety27
Chronic Kidney Disease26
Hypotension25

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms

What next?

Probenecid: the full record: label, generics, price, shortages, recalls
Report a side effect to the FDA: MedWatch
Side effects hub: the most reported medicines and reactions