Prescription and over-the-counter medicine
Clotrimazole Brand names: Cvs, Sunmark, Clotic, Good, Walgreens; first approved as Lotrimin
Clotrimazole (Cvs) is a prescription and over-the-counter medicine with an FDA approval on record since 1975. FDA's NDC Directory lists it from 24 generic labelers, and pharmacies paid $0.133 per gram (Clotrimazole 1% topical cream) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the clotrimazole FDA label on DailyMed (effective January 30, 2026, Glenmark Pharmaceuticals Inc., USA); the NDA 17613 record on Drugs@FDA; every clotrimazole label on DailyMed.
Highlights of the record
FDA label of January 30, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageClotrimazole cream USP is indicated for the topical treatment of candidiasis due to Candida albicans and tinea versicolor due to Malassezia furfur.
Forms and strengths
- 10 mg
- 1 g/100g
- 1.7 mg/.17ml
- 2 g/100g
- 10 mg/g
- 10 mg/ml
Cream; solution; lozenge; spray; liquid.
On the market
- Earliest approval on file
- February 3, 1975 Lotrimin, Schering Plough; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 14 first July 16, 1993; 13 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 29 of which 24 under generic applications, 7 under brand applications, repackagers included; 99 more under the over-the-counter monograph, without an application
- Last listed patent
- May 26, 2042 Clotic solution/drops; not a generic launch date
Supply and safety
- Pharmacy cost (NADAC)
- $0.133 per gram Clotrimazole 1% topical cream
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 0 since 2020 0 Class I among all firms' recalls; 8 more by firms not listed as its makers
- FAERS reports
- 12,230 through July 30, 2026
What is clotrimazole used for?
From the label: indications and usageClotrimazole cream USP is indicated for the topical treatment of candidiasis due to Candida albicans and tinea versicolor due to Malassezia furfur. Clotrimazole is also available as a nonprescription item which is indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis.
Conditions named in the indications of clotrimazole's FDA labels, with every medicine labeled for each:
From other clotrimazole labelsFungal infections: INDICATIONS AND USAGE Clotrimazole cream USP is indicated for the topical treatment of candidiasis due to Candida albicans and tinea versicolor due to Malassezia furfur.
FDA pharmacologic class: Azole Antifungal.
Source: FDA drug label (Clotrimazole), Glenmark Pharmaceuticals Inc., USA, effective January 30, 2026 (SPL set f6898117-14f3-42d2-bc0e-d296add3ad70), via openFDA; the full label on DailyMed
Is there a generic for clotrimazole (Cvs)?
The FDA approved the first generic clotrimazole on July 16, 1993. 14 generic applications are approved; 13 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists clotrimazole from 24 labelers under a generic (ANDA) application and from 7 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
The Orange Book lists no patent for Trivagizole 3 cream; a patent listed only for Clotic solution/drops runs to May 26, 2042. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.
- 1975 earliest approval on file
- 1993 first generic approved
- 2042 last listed patent
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for clotrimazole (Cvs)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.133 per gram (Clotrimazole 1% topical cream), down 6% from $0.141 on October 8, 2025. Prices per unit in the table differ many-fold by strength, form and brand, so compare like with like. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Clotrimazole 1% topical cream (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| 3-day vaginal cream | Generic | $0.312 per gram | n/a | -0.9% |
| Antifungal 1% topical cream | Generic | $0.087 per gram | n/a | -39% |
| Athlete's foot 1% solution | Generic | $2.02 per mL | n/a | -12% |
| Clotrimazole 1% solution | Generic | $1.22 per mL | n/a | -14% |
| Clotrimazole 1% topical cream | Generic | $0.133 per gram | n/a | -6% |
| Clotrimazole 1% vaginal cream | Generic | $0.0895 per gram | n/a | +3% |
| Clotrimazole 10 mg lozenge | Generic | $0.292 per lozenge | n/a | -16% |
| Clotrimazole 10 mg troche | Generic | $0.292 per troche | n/a | -16% |
| Clotrimazole-3 2% cream | Generic | $0.312 per gram | n/a | -0.9% |
| Ft athlete's foot 1% cream | Generic | $0.307 per gram | n/a | +0.6% |
| Ft clotrimazole 1% vag cream | Generic | $0.0895 per gram | n/a | +3% |
| Ft clotrimazole-3 2% cream | Generic | $0.312 per gram | n/a | -0.9% |
| Gnp athlete's foot 1% cream | Generic | $0.142 per gram | n/a | -0.5% |
| Qc clotrimazole 1% vag cream | Generic | $0.0895 per gram | n/a | +3% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has clotrimazole been recalled?
The FDA's Enforcement Report lists 8 recalls naming clotrimazole since 2020: 0 Class I (the most serious), 8 Class II, 0 Class III; 2 still ongoing. 8 of them are by firms that FDA's NDC Directory does not list as a maker of clotrimazole and that hold no application for it in Drugs@FDA, such as compounding pharmacies or bulk-ingredient suppliers; the recall notice names the product recalled. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| October 31, 2025 | Class II | Blossom Pharmaceuticals not a listed maker | cGMP deviations |
| November 17, 2020 | Class II | Taro Pharmaceuticals U.S.A., Inc. not a listed maker | Failed Impurities/Degradation Specifications: An unknown degradation impurity was detected slightly above the specification limit in Clotrimazole Cream USP 1%. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the clotrimazole label say about other medicines?
The clotrimazole label names 3 other medicines in its interaction, contraindication or warning sections. The labels of 7 other medicines name clotrimazole. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Amphotericin b | drug interactions | Drug Interactions Synergism or antagonism between clotrimazole and nystatin, or amphotericin B, or flucytosine against strains of C. albicans has not been reported. |
| Flucytosine | drug interactions | Drug Interactions Synergism or antagonism between clotrimazole and nystatin, or amphotericin B, or flucytosine against strains of C. albicans has not been reported. |
| Nystatin | drug interactions | Drug Interactions Synergism or antagonism between clotrimazole and nystatin, or amphotericin B, or flucytosine against strains of C. albicans has not been reported. |
Other labels that name clotrimazole
Source: FDA drug label (Clotrimazole), Glenmark Pharmaceuticals Inc., USA, effective January 30, 2026 (SPL set f6898117-14f3-42d2-bc0e-d296add3ad70), via openFDA; the full label on DailyMed
What do FAERS reports show for clotrimazole?
The FDA Adverse Event Reporting System holds 12,230 reports that list clotrimazole among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 1,002 are coded as a death and 4,191 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
How does clotrimazole compare with medicines for the same use?
9 side-by-side pages set clotrimazole beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Other azole antifungals
- the pharmacologic class, with prices and generics
- Clotrimazole side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other