What the FDA labels say about taking them together
Clotrimazole and sirolimus
Sirolimus's FDA label of January 28, 2026 names clotrimazole in its drug interactions section; the clotrimazole labels PlainMeds reads (2) do not name sirolimus. The sirolimus label: “Drugs that could increase sirolimus blood concentrations: Bromocriptine, cimetidine, cisapride, clotrimazole, danazol, diltiazem, fluconazole, letermovir, protease inhibitors, metoclopramide, nicardipine …”
Check it at the source: the clotrimazole FDA label on DailyMed (effective January 30, 2026, Glenmark Pharmaceuticals Inc., USA); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the clotrimazole label say about sirolimus?
Clotrimazole's label (effective January 30, 2026) and its 1 other brand-application label do not name sirolimus in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clotrimazole), Glenmark Pharmaceuticals Inc., USA, effective January 30, 2026 (SPL set f6898117-14f3-42d2-bc0e-d296add3ad70), via openFDA; the full label on DailyMed
What does the sirolimus label say about clotrimazole?
Sirolimus label, drug interactionsDrugs that could increase sirolimus blood concentrations: Bromocriptine, cimetidine, cisapride, clotrimazole, danazol, diltiazem, fluconazole, letermovir, protease inhibitors (e.g., HIV and hepatitis C that include drugs such as ritonavir, indinavir, boceprevir, and telaprevir), metoclopramide, nicardipine, troleandomycin, verapamil
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clotrimazole | Sirolimus | |
|---|---|---|
| Labeled for | Fungal infections | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per gram 1% topical cream | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once