What the FDA labels say about taking them together
Clotrimazole and diazepam
Diazepam's FDA label (Valtoco) of June 3, 2026 names clotrimazole in its drug interactions section; the clotrimazole labels PlainMeds reads (2) do not name diazepam. The diazepam label: “Inhibitors of CYP2C19 and CYP3A4 Inhibitors of CYP2C19 and CYP3A4 could decrease the rate of diazepam elimination; therefore, adverse reactions to VALTOCO may be increased.”
Check it at the source: the clotrimazole FDA label on DailyMed (effective January 30, 2026, Glenmark Pharmaceuticals Inc., USA); the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC).
What does the clotrimazole label say about diazepam?
Clotrimazole's label (effective January 30, 2026) and its 1 other brand-application label do not name diazepam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clotrimazole), Glenmark Pharmaceuticals Inc., USA, effective January 30, 2026 (SPL set f6898117-14f3-42d2-bc0e-d296add3ad70), via openFDA; the full label on DailyMed
What does the diazepam label say about clotrimazole?
Valtoco label (Neurelis, Inc, June 3, 2026), drug interactionsInhibitors of CYP2C19 and CYP3A4 Inhibitors of CYP2C19 (e.g., cimetidine, quinidine, and tranylcypromine) and CYP3A4 (e.g., ketoconazole, troleandomycin, and clotrimazole) could decrease the rate of diazepam elimination; therefore, adverse reactions to VALTOCO may be increased.
Source: FDA drug label (Valtoco, NDA211635), Neurelis, Inc, effective June 3, 2026 (SPL set 1a8bcc90-68fa-474d-832c-0df01e825f39), via openFDA
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clotrimazole | Diazepam | |
|---|---|---|
| Labeled for | Fungal infections | Anxiety, Muscle spasms and spasticity |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per gram 1% topical cream | $0.0283 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once