What the FDA labels say about taking them together
Clotrimazole and dihydroergotamine
Dihydroergotamine's FDA label of March 6, 2025 names clotrimazole in its warnings section; the clotrimazole labels PlainMeds reads (2) do not name dihydroergotamine.
Check it at the source: the clotrimazole FDA label on DailyMed (effective January 30, 2026, Glenmark Pharmaceuticals Inc., USA); the dihydroergotamine FDA label on DailyMed (effective March 6, 2025, Oceanside Pharmaceuticals).
What does the clotrimazole label say about dihydroergotamine?
Clotrimazole's label (effective January 30, 2026) and its 1 other brand-application label do not name dihydroergotamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clotrimazole), Glenmark Pharmaceuticals Inc., USA, effective January 30, 2026 (SPL set f6898117-14f3-42d2-bc0e-d296add3ad70), via openFDA; the full label on DailyMed
What does the dihydroergotamine label say about clotrimazole?
Dihydroergotamine label, warningsLess potent inhibitors include saquinavir, nefazodone, fluconazole, grapefruit juice, fluoxetine, fluvoxamine, zileuton, and clotrimazole.
Source: FDA drug label (Trudhesa, NDA213436), Impel Pharmaceuticals LLC, effective September 3, 2026 (SPL set b81397b0-910d-4eb4-8fee-a9a3c9d94d63), via openFDA
Source: FDA drug label (Dihydroergotamine Mesylate), NDA020148 (Bausch), as published by Oceanside Pharmaceuticals, effective March 6, 2025 (SPL set 977de209-c53a-4cb4-9f3f-1e850600a9dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clotrimazole | Dihydroergotamine | |
|---|---|---|
| Labeled for | Fungal infections | Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per gram 1% topical cream | $29.44 per mL 4 mg/mL nasal spray |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once