HIGH-VOLUME · HOSP-HEAVY
sitagliptin Side Effects
sitagliptin (also sold as Januvia) is HIGH-VOLUME in this FAERS book #105 of 524 by FAERS report count. Signature opener: HOSP-HEAVY - 34.6% mention hospitalization (24,338 reports).
Data updated 2026-05-15
- 70,292
- FAERS reports
FAERS voluntary reports, 2006 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
sitagliptin: 34.6% mention hospitalization (24,338 reports). Death stamp DEATH-HEAVY; volume band HIGH-VOLUME #105 of 524 by FAERS report count.
High-report extract for sitagliptin (Januvia): 70,292 FAERS rows (2006-2025). Top named reactions: BLOOD GLUCOSE INCREASED, NAUSEA, DIARRHOEA. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2006–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
BLOOD GLUCOSE INCREASED leads 4,453 of 70,292 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (15,124 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (6,655 reports, 9.5%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 2,153 |
| PANCREATIC CARCINOMA | 960 |
| PANCREATIC CARCINOMA METASTATIC | 442 |
| PNEUMONIA | 393 |
| METASTASES TO LIVER | 381 |
| ACUTE KIDNEY INJURY | 372 |
| HYPERTENSION | 347 |
| RENAL FAILURE | 304 |
| ANAEMIA | 294 |
| DIARRHOEA | 271 |
| DYSPNOEA | 261 |
| MYOCARDIAL INFARCTION | 249 |
| PANCREATITIS | 223 |
| CARDIAC ARREST | 220 |
| CONSTIPATION | 213 |
| CHRONIC KIDNEY DISEASE | 205 |
| ASTHENIA | 203 |
| URINARY TRACT INFECTION | 201 |
| DEHYDRATION | 196 |
| SEPSIS | 196 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (24,338, 34.6% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| NAUSEA | 1,541 |
| ACUTE KIDNEY INJURY | 1,529 |
| PNEUMONIA | 1,387 |
| VOMITING | 1,311 |
| DIARRHOEA | 1,277 |
| FALL | 1,263 |
| DYSPNOEA | 1,260 |
| ASTHENIA | 1,182 |
| PANCREATITIS | 1,182 |
| FATIGUE | 1,165 |
| ANAEMIA | 1,049 |
| PYREXIA | 933 |
| DEHYDRATION | 860 |
| DIZZINESS | 832 |
| BLOOD GLUCOSE INCREASED | 826 |
| MALAISE | 822 |
| HYPOGLYCAEMIA | 818 |
| HYPERTENSION | 775 |
| PAIN | 771 |
| RENAL FAILURE | 763 |
How to read sitagliptin FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 70,292 voluntary reports linked to sitagliptin (Januvia), 2006-2025. Death is listed on 6,655 (9.5%). Hospitalization appears on 24,338 (34.6%). Top co-reported indication: Diabetes Mellitus.
CASELOAD books overweight common drugs and loud reporting cultures; HOSP-HEAVY is the page opener, not a per-patient risk.
Read with sitagliptin
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 70,341 FAERS cases (Δ 49 heavier vs sitagliptin); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 70,203 FAERS cases (Δ 89 lighter vs sitagliptin); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 71,900 FAERS cases (Δ 1,608 heavier vs sitagliptin); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 72,117 FAERS cases (Δ 1,825 heavier vs sitagliptin); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 52.6 pp vs sitagliptin's DEATH-HEAVY): CASELOAD · HOSP-MID.
sitagliptin stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.