Drug side effects
alogliptin Side Effects
The reactions most often reported to the FDA for alogliptin (also sold as Nesina), with demographics, serious outcomes, and reporting trends.
Data updated 2026-05-15
- 3,393
- FAERS reports
Data from the FDA Adverse Event Reporting System (FAERS), 2011 to 2025. A FAERS report records a temporal association, not proof of cause. See our methodology for how figures are compiled and de-duplicated.
The most commonly reported side effects of alogliptin come from 3,393 reports to the FDA, broken down here by frequency, patient demographics, and serious outcomes.
This page analyzes 3,393 reports to the FDA Adverse Event Reporting System (FAERS) for alogliptin (Nesina): the reactions reported most often, who reported them, serious outcomes such as hospitalization, and year-over-year trends. A FAERS report does not prove the drug caused the effect, and report volume tracks how widely a drug is used, not how likely an effect is for any one person. Educational information, not medical advice.
Total Reports
3,393
Reports Mentioning Death
356
10.5% of reports — not proof the medicine caused the death
Hospitalizations
1,564
46.1% of reports
Top Indication
Type 2 Diabetes Mellitus
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 356 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| DEATH | 71 |
| DIARRHOEA | 19 |
| PNEUMONIA | 19 |
| MALIGNANT NEOPLASM PROGRESSION | 18 |
| PYREXIA | 16 |
| INTERSTITIAL LUNG DISEASE | 15 |
| DECREASED APPETITE | 14 |
| CONDITION AGGRAVATED | 13 |
| SUDDEN DEATH | 13 |
| CARDIAC FAILURE | 12 |
| DISSEMINATED INTRAVASCULAR COAGULATION | 12 |
| PEMPHIGOID | 12 |
| VOMITING | 12 |
| CEREBRAL INFARCTION | 11 |
| SEPSIS | 11 |
| DEHYDRATION | 10 |
| PULMONARY ARTERIAL HYPERTENSION | 10 |
| MYOCARDIAL INFARCTION | 9 |
| NAUSEA | 9 |
| PLATELET COUNT DECREASED | 9 |
Reactions in Hospitalization Reports
Top reactions in 1,564 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| ACUTE KIDNEY INJURY | 75 |
| PYREXIA | 62 |
| PNEUMONIA | 60 |
| VOMITING | 58 |
| DIARRHOEA | 57 |
| INTERSTITIAL LUNG DISEASE | 53 |
| DECREASED APPETITE | 51 |
| CEREBRAL INFARCTION | 48 |
| HYPOGLYCAEMIA | 46 |
| NAUSEA | 44 |
| FALL | 43 |
| BLOOD GLUCOSE INCREASED | 41 |
| CONDITION AGGRAVATED | 41 |
| DIABETIC KETOACIDOSIS | 41 |
| LACTIC ACIDOSIS | 40 |
| PEMPHIGOID | 40 |
| MALAISE | 39 |
| CONSTIPATION | 38 |
| PANCREATITIS ACUTE | 38 |
| RASH | 36 |
Nearby, Related Medications
What the FAERS Data Reveals About alogliptin Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 3,393 voluntary reports linked to alogliptin and its brand equivalents (Nesina), spanning 2011 through 2025. Of those, 356 (10.5%) listed death as an outcome and 1,564 (46.1%) involved hospitalization. The most common indication reported alongside adverse events was Type 2 Diabetes Mellitus.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 42% were female and 58% male; age distribution skews toward 75+, with 885 reports in that bracket. The single most reported reaction is diarrhoea with 134 submissions, followed by nausea and vomiting.
How to read these numbers
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice, speak with a licensed clinician about any side-effect concerns.
Drugs With a Similar FAERS Report Volume
Other medications with a total FDA adverse-event report count closest to alogliptin's 3,393.
Read our methodology - how this data is sourced, computed, and verified.