Prescription medicine

Rimantadine First approved as Flumadine

Rimantadine (Flumadine) is a prescription medicine with an FDA approval on record since 1993. FDA's NDC Directory lists it from 1 generic labeler.

Generic listed

Check it at the source: the rimantadine FDA label on DailyMed (effective December 31, 2023, Amneal Pharmaceuticals of New York LLC); the NDA 19650 record on Drugs@FDA; every rimantadine label on DailyMed.

Highlights of the record

FDA label of December 31, 2023; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026

Used for

From the label: indications and usage
Rimantadine hydrochloride tablet is indicated for the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults (17 years and older).

Forms and strengths

100 mg

Film-coated tablet.

On the market

Earliest approval on file: September 17, 1993 Flumadine, Forest Labs; Drugs@FDA’s file, where older or withdrawn approvals can be missing
Generic approvals: 3 first November 2, 2001; 1 with a marketed status in Drugs@FDA
Labelers listed (NDC): 1 of which 1 under generic applications, 0 under brand applications, repackagers included

Supply and safety

Pharmacy cost (NADAC): Not in the survey
Shortage (FDA): No current entry
Recalls by its makers (FDA): No recall recorded
FAERS reports: 26 through July 30, 2026

What is rimantadine used for?

From the label: indications and usage
Rimantadine hydrochloride tablet is indicated for the prophylaxis and treatment of illness caused by various strains of influenza A virus in adults (17 years and older). Rimantadine hydrochloride tablet is indicated for prophylaxis against influenza A virus in children (1 year to 16 years of age). Prophylaxis In controlled studies of children (1 year to 16 years of age), healthy adults (17 years and older), and elderly patients (65 years of age and older), rimantadine hydrochloride has been shown to be safe and effective in preventing signs and symptoms of infection caused by various strains of influenza A virus. […]

Conditions named in the indications of rimantadine's FDA labels, with every medicine labeled for each:

Influenza

FDA pharmacologic class: Influenza A M2 Protein Inhibitor.

Source: FDA drug label (Rimantadine Hydrochloride), ANDA076132 (Impax Labs), as published by Amneal Pharmaceuticals of New York LLC, effective December 31, 2023 (SPL set 49f7d69a-820b-4c75-a31d-b2104c019c12), via openFDA; the full label on DailyMed

Is there a generic for rimantadine (Flumadine)?

The FDA approved the first generic rimantadine on November 2, 2001. 3 generic applications are approved; 1 of them carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.

FDA's NDC Directory lists rimantadine from 1 labeler under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.

1993 earliest approval on file
2001 first generic approved

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What does the rimantadine label say about other medicines?

The rimantadine label names 4 other medicines in its interaction, contraindication or warning sections. The labels of 1 other medicine name rimantadine. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Medicine named	Section	What the label says
Acetaminophen	drug interactions	Co-administration with acetaminophen reduced the peak concentration and AUC values for rimantadine by approximately 11%.
Amantadine	contraindications	CONTRAINDICATIONS Rimantadine hydrochloride tablet is contraindicated in patients with known hypersensitivity to drugs of the adamantane class, including rimantadine and amantadine.
Aspirin	drug interactions	Peak plasma concentrations and AUC of rimantadine were reduced approximately 10% in the presence of aspirin.
Cimetidine	drug interactions	When a single 100 mg dose of rimantadine hydrochloride was administered with steady-state cimetidine (300 mg four times a day), there were no statistically significant differences in rimantadine C max or AUC between rimantadine hydrochloride alone and rimantadine hydrochloride in the presence of cimetdine.

Check rimantadine against other medicines

What do FAERS reports show for rimantadine?

The FDA Adverse Event Reporting System holds 26 reports that list rimantadine among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 6 are coded as a death and 10 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

The most reported reactions

Drug Ineffective (a use or a product term, not a reaction)4
Malaise3
Convulsion (named in the label)2
Drug Resistance2
Febrile Neutropenia2
Hyperhidrosis2
Hyperkalaemia2
Myocardial Infarction2

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026

What else is labeled for the same conditions as rimantadine?

3 other medicines are given the same way (oral) and in the same FDA class as rimantadine or labeled mainly for the same use (influenza), the same class first. Influenza lists all 5 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.

Medicine	Shared indication	Generic labelers (oral)	Pharmacy cost	Shortage
Amantadine	Influenza	34 labelers	$0.143 per capsule 100 mg capsule	No current entry
Oseltamivir	Influenza	36 labelers	$0.150 per mL 6 mg/mL suspension	No current entry
Baloxavir marboxil	Influenza	none listed	$161.94 per tablet 40 mg tablet	No current entry

Every medicine labeled for the same conditions as rimantadine

Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)

What next?

Alternatives to rimantadine: 3 medicines for the same use
Other influenza a m2 protein inhibitors: the pharmacologic class, with prices and generics
Rimantadine side effects: the label's list beside FAERS reports
Check an interaction: what two or more labels say about each other