What the FDA labels say about taking them together
Acetaminophen and rimantadine
Rimantadine's FDA label of December 31, 2023 names acetaminophen in its drug interactions section; the acetaminophen labels PlainMeds reads (4) do not name rimantadine. The rimantadine label: “Co-administration with acetaminophen reduced the peak concentration and AUC values for rimantadine by approximately 11%.”
Check it at the source: the acetaminophen FDA label on DailyMed (effective November 13, 2024, Kenvue Brands LLC); the rimantadine FDA label on DailyMed (effective December 31, 2023, Amneal Pharmaceuticals of New York LLC).
What does the acetaminophen label say about rimantadine?
Acetaminophen's label (effective November 13, 2024) and its 3 other brand-application labels do not name rimantadine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tylenol 8 HR Arthritis Pain), Kenvue Brands LLC, effective November 13, 2024 (SPL set 3af22fc8-e4e0-4863-8696-6bc1257047cb), via openFDA; the full label on DailyMed
What does the rimantadine label say about acetaminophen?
Rimantadine label, drug interactionsCo-administration with acetaminophen reduced the peak concentration and AUC values for rimantadine by approximately 11%.
Source: FDA drug label (Rimantadine Hydrochloride), ANDA076132 (Impax Labs), as published by Amneal Pharmaceuticals of New York LLC, effective December 31, 2023 (SPL set 49f7d69a-820b-4c75-a31d-b2104c019c12), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen | Rimantadine | |
|---|---|---|
| Labeled for | Fever, Cough and cold, Pain | Influenza |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0339 per unit 500 mg caplet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once