HIGH-VOLUME · FEMALE-LED
cyclobenzaprine Side Effects
cyclobenzaprine (also sold as Flexeril, Amrix) is HIGH-VOLUME in this FAERS book #147 of 524 by FAERS report count. Signature opener: FEMALE-LED - 72% of sex-coded reports are female (31,623 F / 12,204 M).
Data updated 2026-05-15
- 47,426
- FAERS reports
FAERS voluntary reports, 2003 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
cyclobenzaprine reporting skew - 72% of sex-coded reports are female (31,623 F / 12,204 M). Volume band HIGH-VOLUME #147 of 524 by FAERS report count; caseload CASELOAD.
High-report extract for cyclobenzaprine (Flexeril): 47,426 FAERS rows (2003-2025). Top named reactions: PAIN, FATIGUE, NAUSEA. Outcome stamps DEATH-HEAVY · HOSP-MID · FEMALE-LED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2003–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
PAIN leads 4,871 of 47,426 reports
FEMALE-LED reporters · age peak 45-64
Female-led reporters (72% of sex-coded rows)
Age peak 45-64 (15,065 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (6,863 reports, 14.5%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 1,948 |
| DEATH | 1,521 |
| TOXICITY TO VARIOUS AGENTS | 1,465 |
| DRUG ABUSE | 919 |
| CARDIO-RESPIRATORY ARREST | 478 |
| CARDIAC ARREST | 427 |
| HYPERTENSION | 376 |
| RESPIRATORY ARREST | 364 |
| OVERDOSE | 331 |
| PAIN | 322 |
| HEPATIC ENZYME INCREASED | 316 |
| INFUSION RELATED REACTION | 309 |
| PNEUMONIA | 308 |
| RHEUMATOID ARTHRITIS | 303 |
| BURSITIS | 298 |
| FATIGUE | 292 |
| CONTRAINDICATED PRODUCT ADMINISTERED | 281 |
| ASTHENIA | 276 |
Reactions in Hospitalization Reports
Hospitalization mid-share (13,293, 28.0%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| PAIN | 1,737 |
| FALL | 1,481 |
| NAUSEA | 1,120 |
| DYSPNOEA | 1,111 |
| PNEUMONIA | 1,098 |
| HYPOTENSION | 1,052 |
| TOXICITY TO VARIOUS AGENTS | 1,049 |
| FATIGUE | 1,036 |
| CONSTIPATION | 990 |
| HEADACHE | 844 |
| VOMITING | 835 |
| DIARRHOEA | 821 |
| ACUTE KIDNEY INJURY | 806 |
| MOBILITY DECREASED | 731 |
| ANXIETY | 720 |
| ARTHRALGIA | 714 |
| BALANCE DISORDER | 711 |
| DEPRESSED LEVEL OF CONSCIOUSNESS | 708 |
| ASTHENIA | 703 |
How to read cyclobenzaprine FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-MID)
FAERS holds 47,426 voluntary reports linked to cyclobenzaprine (Flexeril, Amrix), 2003-2025. Death is listed on 6,863 (14.5%). Hospitalization appears on 13,293 (28.0%). Top co-reported indication: Product Used For Unknown Indication.
CASELOAD books overweight common drugs and loud reporting cultures; FEMALE-LED is the page opener, not a per-patient risk.
Read with cyclobenzaprine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 47,513 FAERS cases (Δ 87 heavier vs cyclobenzaprine); DEATH-MARKED · HOSP-LIGHT · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 47,215 FAERS cases (Δ 211 lighter vs cyclobenzaprine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 47,788 FAERS cases (Δ 362 heavier vs cyclobenzaprine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 47,843 FAERS cases (Δ 417 heavier vs cyclobenzaprine); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 47.6 pp vs cyclobenzaprine's DEATH-HEAVY): CASELOAD · HOSP-MID.
cyclobenzaprine stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.