Drug side effects
exenatide Side Effects
The reactions most often reported to the FDA for exenatide (also sold as Byetta, Bydureon), with demographics, serious outcomes, and reporting trends.
Data updated 2026-05-15
- 52,302
- FAERS reports
Data from the FDA Adverse Event Reporting System (FAERS), 2005 to 2025. A FAERS report records a temporal association, not proof of cause. See our methodology for how figures are compiled and de-duplicated.
The most commonly reported side effects of exenatide come from 52,302 reports to the FDA, broken down here by frequency, patient demographics, and serious outcomes.
This page analyzes 52,302 reports to the FDA Adverse Event Reporting System (FAERS) for exenatide (Byetta): the reactions reported most often, who reported them, serious outcomes such as hospitalization, and year-over-year trends. A FAERS report does not prove the drug caused the effect, and report volume tracks how widely a drug is used, not how likely an effect is for any one person. Educational information, not medical advice.
Total Reports
52,302
Reports Mentioning Death
1,762
3.4% of reports — not proof the medicine caused the death
Hospitalizations
7,532
14.4% of reports
Top Indication
Type 2 Diabetes Mellitus
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 1,762 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| PANCREATIC CARCINOMA | 765 |
| DEATH | 346 |
| PANCREATIC CARCINOMA METASTATIC | 268 |
| METASTASES TO LIVER | 178 |
| RENAL FAILURE | 94 |
| PANCREATITIS | 91 |
| ADENOCARCINOMA PANCREAS | 90 |
| NAUSEA | 82 |
| WEIGHT DECREASED | 77 |
| HYPERTENSION | 74 |
| JAUNDICE CHOLESTATIC | 65 |
| METASTASES TO LUNG | 64 |
| MYOCARDIAL INFARCTION | 60 |
| PANCREATITIS ACUTE | 60 |
| VOMITING | 58 |
| ASCITES | 53 |
| ACUTE KIDNEY INJURY | 52 |
| METASTASES TO LYMPH NODES | 51 |
| CHOLELITHIASIS | 45 |
| BLADDER CANCER | 44 |
Reactions in Hospitalization Reports
Top reactions in 7,532 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| WEIGHT DECREASED | 1,332 |
| NAUSEA | 1,199 |
| BLOOD GLUCOSE INCREASED | 1,150 |
| PANCREATITIS | 1,033 |
| VOMITING | 813 |
| PANCREATITIS ACUTE | 574 |
| DIARRHOEA | 483 |
| DECREASED APPETITE | 481 |
| BLOOD GLUCOSE DECREASED | 431 |
| DEHYDRATION | 377 |
| RENAL FAILURE | 360 |
| DIZZINESS | 333 |
| FALL | 331 |
| ABDOMINAL PAIN | 329 |
| DYSPNOEA | 325 |
| RENAL FAILURE ACUTE | 306 |
| ASTHENIA | 296 |
| MYOCARDIAL INFARCTION | 272 |
| MALAISE | 271 |
Nearby, Related Medications
What the FAERS Data Reveals About exenatide Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 52,302 voluntary reports linked to exenatide and its brand equivalents (Byetta, Bydureon), spanning 2005 through 2025. Of those, 1,762 (3.4%) listed death as an outcome and 7,532 (14.4%) involved hospitalization. The most common indication reported alongside adverse events was Type 2 Diabetes Mellitus.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 64% were female and 36% male; age distribution skews toward 45-64, with 20,550 reports in that bracket. The single most reported reaction is blood glucose increased with 15,472 submissions, followed by weight decreased and nausea.
How to read these numbers
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice, speak with a licensed clinician about any side-effect concerns.
Drugs With a Similar FAERS Report Volume
Other medications with a total FDA adverse-event report count closest to exenatide's 52,302.
Read our methodology - how this data is sourced, computed, and verified.