Prescription and over-the-counter medicine
Dimenhydrinate
Dimenhydrinate is a prescription and over-the-counter medicine. FDA's NDC Directory lists it from 1 generic labeler, and pharmacies paid $0.0575 per driminate 50 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the dimenhydrinate FDA label on DailyMed (effective August 17, 2026); every dimenhydrinate label on DailyMed.
Highlights of the record
FDA label of August 17, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usagefor prevention and treatment of these symptoms associated with motion sickness: nausea vomiting dizziness
Forms and strengths
- 50 mg/ml
Injection (solution).
On the market
- Generic approvals
- 7 first May 31, 1972; 1 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 1 of which 1 under generic applications, 0 under brand applications, repackagers included; 22 more under the over-the-counter monograph, without an application
Supply and safety
- Pharmacy cost (NADAC)
- $0.0575 per tablet Driminate 50 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 10,594 through July 30, 2026
What is dimenhydrinate used for?
From the label: indications and usagefor prevention and treatment of these symptoms associated with motion sickness: nausea vomiting dizziness
Conditions named in the indications of dimenhydrinate's FDA labels, with every medicine labeled for each:
From other dimenhydrinate labelsNausea and vomiting: Uses For the prevention and treatment of the nausea, vomiting and dizziness associated with motion sickness
Source: FDA drug label (Motion Sickness), Strategic Sourcing Services LLC, effective August 17, 2026 (SPL set be8f91d4-6e4f-4d47-93e9-7fb91160b7df), via openFDA; the full label on DailyMed
Is there a generic for dimenhydrinate?
The FDA approved the first generic dimenhydrinate on May 31, 1972. 7 generic applications are approved; 1 of them carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists dimenhydrinate from 1 labeler under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for dimenhydrinate?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $0.0575 per Driminate 50 mg tablet, down 16% from $0.0686 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Driminate 50 mg tablet (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Driminate 50 mg tablet | Generic | $0.0575 per tablet | $1.73 | -16% |
| Ft motion sickness 50 mg tablet | Generic | $0.0575 per tablet | $1.73 | -16% |
| Motion sickness 50 mg tablet | Generic | $0.0575 per tablet | $1.73 | -16% |
| Qc motion sickness 50 mg tablet | Generic | $0.0575 per tablet | $1.73 | -16% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What does the dimenhydrinate label say about other medicines?
The dimenhydrinate label names 1 other medicine in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Diphenhydramine | contraindications (prescription label) | CONTRAINDICATIONS Neonates and patients with a history of hypersensitivity to dimenhydrinate or its components (diphenhydramine or 8-chlorotheophylline) should not be treated with dimenhydrinate. |
Source: FDA drug label (Motion Sickness), Strategic Sourcing Services LLC, effective August 17, 2026 (SPL set be8f91d4-6e4f-4d47-93e9-7fb91160b7df), via openFDA; the full label on DailyMed
What do FAERS reports show for dimenhydrinate?
The FDA Adverse Event Reporting System holds 10,594 reports that list dimenhydrinate among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 835 are coded as a death and 5,116 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as dimenhydrinate?
7 other medicines are given the same way (oral) and in the same FDA class as dimenhydrinate or labeled mainly for the same use (nausea and vomiting), the same class first. Nausea and vomiting lists all 16 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Ondansetron | Nausea and vomiting | 60 labelers | $0.0582 per tablet 4 mg tablet | No current entry |
| Meclizine | Nausea and vomiting | 24 labelers | $0.0442 per tablet 12.5 mg tablet | No current entry |
| Prochlorperazine | Nausea and vomiting | 29 labelers | $0.162 per tablet 10 mg tablet | No current entry |
| Aprepitant | Nausea and vomiting | 5 labelers | $46.42 per capsule 40 mg capsule | A presentation being discontinued |
| Doxylamine and pyridoxine | Nausea and vomiting | 4 labelers | $1.09 per unit 10-10 mg | No current entry |
| Trimethobenzamide | Nausea and vomiting | 4 labelers | n/a | No current entry |
| Tradipitant | Nausea and vomiting | none listed | n/a | No current entry |
Every medicine labeled for the same conditions as dimenhydrinate
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
How does dimenhydrinate compare with medicines for the same use?
3 side-by-side pages set dimenhydrinate beside a medicine whose label shares a use: approvals, generics, pharmacy cost, warnings and supply.
What next?
- Alternatives to dimenhydrinate
- 7 medicines for the same use
- Dimenhydrinate side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other