FDA pharmacologic class
Phenothiazine
7 medicines are in FDA's class of phenothiazines: promethazine (Phenergan), chlorpromazine, fluphenazine, prochlorperazine (Compro), perphenazine, trifluoperazine and thioridazine; 5 combination products also contain one. All 12 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is promethazine-dm 6.25-15 mg/5 ml solution at $0.039 per mL (NADAC).
Which medicines are phenothiazine?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Promethazine | Phenergan, Promethegan | 47 labelers | $0.0455 per tablet 25 mg tablet | No | In shortage | 2 |
| Chlorpromazine | none listed | 33 labelers | $0.552 per tablet 100 mg tablet | Yes | No current entry | 25 |
| Fluphenazine | none listed | 36 labelers | $0.431 per tablet 10 mg tablet | Yes | No current entry | 11 |
| Prochlorperazine | Compro | 45 labelers | $0.162 per tablet 10 mg tablet | Yes | No current entry | 3 |
| Perphenazine | none listed | 16 labelers | $0.161 per tablet 4 mg tablet | Yes | No current entry | 1 |
| Trifluoperazine | none listed | 6 labelers | $0.579 per tablet 2 mg tablet | Yes | No current entry | 0 |
| Thioridazine | none listed | 5 labelers | $0.571 per tablet 25 mg tablet | Yes | No current entry | 0 |
| Dextromethorphan and promethazine | none listed | 12 labelers | $0.039 per mL 6.25-15 mg/5 mL solution | Yes | No current entry | 0 |
| Amitriptyline and perphenazine | none listed | 1 labeler | n/a | Yes | No current entry | 0 |
| Codeine and promethazine | none listed | 5 labelers | $0.0697 per mL Promethazine-codeine solution | Yes | No current entry | 0 |
| Phenylephrine and promethazine | none listed | 2 labelers | n/a | No | No current entry | 0 |
| Codeine and phenylephrine and promethazine | none listed | 1 labeler | n/a | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price