FDA pharmacologic class
Atypical antipsychotics
15 medicines are in FDA's class of atypical antipsychotics (atypical antipsychotics): quetiapine (Seroquel), aripiprazole (Abilify), olanzapine (Zyprexa), risperidone (Risperdal), lurasidone (Latuda), paliperidone (Invega), ziprasidone (Geodon), clozapine (Clozaril) and 7 more; 2 combination products also contain one. 13 of the 17 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is risperidone 0.25 mg tablet at $0.0368 per tablet (NADAC).
Which medicines are atypical antipsychotics?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Quetiapine | Seroquel | 48 labelers | $0.127 per tablet 300 mg tablet | Yes | No current entry | 10 |
| Aripiprazole | Abilify, Opipza | 47 labelers | $0.110 per tablet 5 mg tablet | Yes | No current entry | 25 |
| Olanzapine | Zyprexa | 43 labelers | $0.147 per tablet 20 mg tablet | Yes | No current entry | 14 |
| Risperidone | Risperdal, Uzedy, Rykindo | 37 labelers | $0.0368 per tablet 0.25 mg tablet | Yes | No current entry | 5 |
| Lurasidone | Latuda | 28 labelers | $0.142 per tablet 20 mg tablet | Yes | No current entry | 2 |
| Paliperidone | Invega, Erzofri | 18 labelers | $0.972 per tablet 3 mg tablet | Yes | No current entry | 5 |
| Ziprasidone | Geodon | 23 labelers | $0.269 per capsule 20 mg capsule | Yes | No current entry | 1 |
| Clozapine | Clozaril, Versacloz | 11 labelers | $0.610 per tablet 100 mg tablet | Yes | No current entry | 4 |
| Asenapine | Saphris, Secuado | 5 labelers | $2.63 per tablet 10 mg tablet sl | Yes | No current entry | 3 |
| Iloperidone | Fanapt | 1 labeler | $60.01 per tablet 12 mg tablet | Yes | No current entry | 0 |
| Brexpiprazole | Rexulti | 1 labeler | $49.50 per tablet 0.25 mg tablet | Yes | No current entry | 0 |
| Fluoxetine and olanzapine | none listed | 3 labelers | $3.44 per unit 3-25 mg | Yes | No current entry | 0 |
| Cariprazine | Vraylar | none listed | $50.84 per capsule 1.5 mg capsule | Yes | No current entry | 0 |
| Aripiprazole lauroxil | Aristada | none listed | $993.60 per mL 1,064 mg/3.9 mL syringe | Yes | No current entry | 0 |
| Olanzapine and samidorphan l-malate | Lybalvi | none listed | $55.10 per tablet 10-10 mg tablet | Yes | No current entry | 0 |
| Lumateperone | Caplyta | none listed | $57.24 per capsule 10.5 mg capsule | Yes | No current entry | 0 |
| Pimavanserin | Nuplazid | 1 labeler | $170.50 per capsule 34 mg capsule | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price