Medicines labeled for the same conditions
Alternatives to hydrocodone and ibuprofen
39 other medicines are given the same way (oral) and in the same FDA class as hydrocodone and ibuprofen or labeled mainly for the same use (pain); 24 are in its class, opioid agonists: naproxen, celecoxib, diclofenac, acetaminophen and aspirin and caffeine and 20 more; the others include 1 cholinergic muscarinic antagonist, 1 partial opioid agonist/antagonist and 1 sodium channel blocker (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0166 per meloxicam 7.5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as hydrocodone and ibuprofen?
The first 24 of the 39, the same class first. Pain lists all 80 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Hydrocodone and ibuprofenopioid agonist | this medicine | 2 labelers | $0.487 per unit 7.5-200 | Yes | No current entry |
| Naproxennonsteroidal anti-inflammatory drug · same class | Pain | 146 labelers | $0.0565 per tablet 500 mg tablet | Yes | No current entry |
| Celecoxibnonsteroidal anti-inflammatory drug · same class | Pain | 65 labelers | $0.0762 per capsule 200 mg capsule | Yes | No current entry |
| Diclofenacnonsteroidal anti-inflammatory drug · same class | Pain | 67 labelers | $0.0619 per tablet 75 mg tablet | Yes | A presentation being discontinued |
| Acetaminophen and aspirin and caffeineplatelet aggregation inhibitor · same class | Pain | 39 labelers | $0.0648 per unit 250-250-65 mg cplt | No | No current entry |
| Oxycodoneopioid agonist · same class | Pain | 34 labelers | $0.0884 per tablet 5 mg tablet | Yes | No current entry |
| Meloxicamnonsteroidal anti-inflammatory drug · same class | Pain | 43 labelers | $0.0166 per tablet 7.5 mg tablet | Yes | No current entry |
| Acetaminophen and oxycodoneopioid agonist · same class | Pain | 30 labelers | $0.183 per tablet 7.5-325 mg tablet | Yes | A presentation being discontinued |
| Tramadolopioid agonist · same class | Pain | 40 labelers | $0.0248 per tablet 50 mg tablet | Yes | No current entry |
| Morphineopioid agonist · same class | Pain | 17 labelers | $0.226 per tablet 15 mg tablet | Yes | In shortage |
| Etodolacnonsteroidal anti-inflammatory drug · same class | Pain | 30 labelers | $0.262 per tablet 400 mg tablet | Yes | No current entry |
| Acetaminophen and codeineopioid agonist · same class | Pain | 25 labelers | $0.256 per tablet 3 tablet | Yes | No current entry |
| Ketorolaccyclooxygenase inhibitor · same class | Pain | 33 labelers | $0.164 per tablet 10 mg tablet | Yes | In shortage |
| Hydromorphoneopioid agonist · same class | Pain | 11 labelers | $0.219 per tablet 4 mg tablet | Yes | In shortage |
| Methadoneopioid agonist · same class | Pain | 17 labelers | $0.177 per tablet 10 mg tablet | Yes | No current entry |
| Oxymorphoneopioid agonist · same class | Pain | 9 labelers | n/a | Yes | No current entry |
| Tapentadolopioid agonist · same class | Pain | 4 labelers | $14.48 per tablet 100 mg tablet | Yes | No current entry |
| Acetaminophen and tramadolopioid agonist · same class | Pain | 12 labelers | $0.116 per tablet 37.5-325 mg tablet | Yes | No current entry |
| Fenoprofennonsteroidal anti-inflammatory drug · same class | Pain | 6 labelers | n/a | Yes | No current entry |
| Levorphanolopioid agonist · same class | Pain | 7 labelers | $10.65 per tablet 2 mg tablet | Yes | No current entry |
| Acetaminophen, butalbital, caffeine and codeinebarbiturate · same class | Pain | 5 labelers | $0.798 per capsule 50-325-40-30 mg capsule | Yes | No current entry |
| Diflunisalnonsteroidal anti-inflammatory drug · same class | Pain | 6 labelers | $1.06 per tablet 500 mg tablet | Yes | No current entry |
| Ketoprofennonsteroidal anti-inflammatory drug · same class | Pain | 5 labelers | $6.46 per capsule 200 mg capsule | Yes | No current entry |
| Codeineopioid agonist · same class | Pain | 1 labeler | $0.726 per tablet 30 mg tablet | Yes | No current entry |
| Mefenamic acidnonsteroidal anti-inflammatory drug · same class | Pain | 6 labelers | $0.948 per capsule 250 mg capsule | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Hydrocodone and ibuprofen: the full record
- label, generics, price, shortages, recalls