Alternatives to desipramine
FDA shortage status is active for desipramine; 6 same-class SPL records are listed below for registry comparison only.
Brand: Norpramin
desipramine class peers while FDA lists an active shortage
desipramine (Norpramin) is on an FDA shortage listing while 6 other Tricyclic Antidepressant (TCA) SPL records remain in this registry peer set (class inventory 7). Labeled indication field for desipramine: Desipramine is used to treat depression.
Top FAERS reaction fields for desipramine total 743 reports across 10 reactions, set beside amitriptyline, clomipramine, doxepin. Counts are exposure-weighted submissions, not per-patient risk.
About desipramine
Desipramine is a medicine used to treat depression. It belongs to a class of drugs called tricyclic antidepressants.
Used for: Desipramine is used to treat depression. Depression can cause feelings of sadness, loss of interest, and trouble functioning in daily life. This medicine can help improve your mood and overall well-being.
6 Tricyclic Antidepressant (TCA) peers (wide set)
amitriptyline
RxElavil
Amitriptyline is used to relieve the symptoms of depression. It works best for a type of depression called endogenous depression. This is depression that comes from within, rather than being caused by outside events.
clomipramine
RxAnafranil
Clomipramine treats obsessive-compulsive disorder (OCD). OCD causes upsetting thoughts or images that keep coming back. It also causes the need to repeat actions over and over. Clomipramine can help control these symptoms.
doxepin
RxSinequan, Silenor
Doxepin is used to treat insomnia, which means you have trouble staying asleep. It can help you sleep better if you have problems with waking up during the night. This medicine has been tested for up to 3 months.
imipramine
RxTofranil
This medicine can help relieve the symptoms of depression. It may work better for some types of depression than others. Imipramine can also be used to help reduce bedwetting in children 6 years and older, but only after a doctor has ruled out other possible causes.
nortriptyline
RxPamelor
Nortriptyline is used to relieve the symptoms of depression. It may work better for some types of depression than others. Talk to your doctor to see if nortriptyline is right for you.
protriptyline
RxVivactil
Protriptyline is used to treat symptoms of mental depression. It is especially helpful for people who are withdrawn and lack energy. Your doctor will monitor you closely while you are taking this medicine.
desipramine vs amitriptyline & clomipramine · FAERS reaction fields
FAERS top-reaction field "Nausea" shows the widest count spread between desipramine and amitriptyline, clomipramine, doxepin in this extract (1,357-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | desipramine | amitriptyline | clomipramine | doxepin |
|---|---|---|---|---|
| Fatigue | 119 | 1,371 | 136 | 599 |
| Completed Suicide | 116 | - | - | 613 |
| Nausea | 77 | 1,434 | 173 | 557 |
| Headache | 70 | 1,381 | - | 482 |
| Weight Increased | 68 | - | - | - |
| Dizziness | 63 | 1,153 | 136 | 405 |
| Toxicity To Various Agents | 60 | - | - | 801 |
| Pain | 59 | 1,565 | - | 527 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
desipramine shortage vs Tricyclic Antidepressant (TCA) peer index
Shortage status
FDA shortage listing is active for desipramine (status: To Be Discontinued). Peer rows remain a registry index, not a switch guide.
Frequently Asked Questions
Does FDA list a shortage for desipramine while peers remain indexed? ▼
Registry note: Shortage listings and peer indexes are for registry orientation only. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for desipramine: see also the generic vs brand label guide when reading Norpramin SPL strings.
Read our methodology - how this data is sourced, computed, and verified.