Alternatives to clozapine
11 same-class SPL records vs clozapine - uses, FAERS reaction fields, and OTC/Rx flags from public FDA sources.
Brand: Clozaril
How to read a high-report FAERS peer set
clozapine ranks in the upper FAERS-volume third of the corpus (#61 of 524); 11 same-class peers are listed for field comparison only. Labeled indication field for clozapine: Versacloz is used to treat schizophrenia in people who haven't responded well to other antipsychotic medicines.
Top FAERS reaction fields for clozapine total 69,618 reports across 10 reactions, set beside aripiprazole, asenapine, brexpiprazole. Counts are exposure-weighted submissions, not per-patient risk.
About clozapine
Versacloz is a medicine used to treat severe schizophrenia when other medicines have not worked. It can also help lower the risk of suicidal behavior in people with schizophrenia or schizoaffective disorder.
Used for: Versacloz is used to treat schizophrenia in people who haven't responded well to other antipsychotic medicines. Schizophrenia is a mental illness that can cause hallucinations, delusions, and disorganized thinking. Versacloz can also help lower the risk of repeated suicidal behavior in people with schizophrenia or schizoaffective disorder who are at high risk.
11 Atypical Antipsychotic peers (wide set)
aripiprazole
RxAbilify
Aripiprazole is used to treat schizophrenia in adults and teens. It also treats irritability in children with autism. Additionally, it can treat Tourette's disorder.
asenapine
RxSaphris
Asenapine is used to treat bipolar I disorder. In children ages 10 to 17, it can treat manic or mixed episodes on its own. In adults, it can be used with lithium or valproate to treat these episodes.
brexpiprazole
RxRexulti
Rexulti can be used with antidepressants to treat major depressive disorder in adults. It can also treat schizophrenia in adults and children 13 years and older. Additionally, Rexulti can help manage agitation in people with dementia due to Alzheimer's disease. Rexulti should not be used as needed for agitation related to dementia.
cariprazine
RxVraylar
Vraylar can treat schizophrenia in adults and kids 13 and older. It also treats manic or mixed episodes of bipolar I disorder in adults and kids 10 and older. In adults, Vraylar treats the depressive episodes of bipolar I disorder. Vraylar can also be used with antidepressants to treat major depressive disorder in adults.
iloperidone
RxFanapt
Fanapt is used to treat schizophrenia in adults. Schizophrenia can cause confused thinking, hallucinations, and changes in behavior. Fanapt is also used for the short-term treatment of manic or mixed episodes linked to bipolar I disorder in adults.
lurasidone
RxLatuda
Lurasidone is used to treat schizophrenia in adults and teens ages 13-17. It also treats the depressive phase of bipolar disorder in adults and children ages 10-17. In adults, it can be used alone or with lithium or valproate for bipolar depression.
olanzapine
RxZyprexa
Olanzapine is used to treat schizophrenia in adults and teens (13-17). It also treats manic or mixed episodes of bipolar I disorder in adults and teens (13-17). In adults, it can be used with other medicines to treat bipolar depression.
paliperidone
RxInvega
This medicine is used to treat schizophrenia in adults and teens (12-17 years old). It can also treat schizoaffective disorder in adults, either alone or with other medicines like mood stabilizers or antidepressants. Schizophrenia can cause hallucinations, delusions, and confused thinking. Schizoaffective disorder includes symptoms of both schizophrenia and mood disorders.
quetiapine
RxSeroquel
Quetiapine is used to treat schizophrenia in adults and teens (13-17 years old). It also treats manic and depressive episodes of bipolar disorder in adults and children (10-17 years old). For bipolar disorder, it can be used alone or with other medicines like lithium or divalproex.
risperidone
RxRisperdal
Risperidone is used to treat schizophrenia in adults and teens. It also treats manic or mixed episodes of bipolar I disorder, either alone or with lithium or valproate. Additionally, it can help with irritability, including aggression and self-injury, in children and teens with autism.
ziprasidone
RxGeodon
Ziprasidone treats schizophrenia in adults. It also treats manic or mixed episodes of bipolar I disorder, either alone or with lithium or valproate. This medicine can help manage mood swings and improve overall mental well-being.
clozapine vs aripiprazole & asenapine · FAERS reaction fields
FAERS top-reaction field "Neutropenia" shows the widest count spread between clozapine and aripiprazole, asenapine, brexpiprazole in this extract (18,655-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | clozapine | aripiprazole | asenapine | brexpiprazole |
|---|---|---|---|---|
| Neutropenia | 18,655 | - | - | - |
| Hospitalisation | 12,101 | - | - | - |
| Death | 11,398 | - | - | 428 |
| Schizophrenia | 4,547 | - | - | - |
| White Blood Cell Count Increased | 4,444 | - | - | - |
| White Blood Cell Count Decreased | 4,370 | - | - | - |
| Neutrophil Count Increased | 4,114 | - | - | - |
| Malaise | 3,706 | - | - | - |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
clozapine FAERS volume vs class peers
FAERS volume band
clozapine is FAERS corpus rank #61 of 524 (high volume tercile). Top-reaction field total: 69,618.
Frequently Asked Questions
Where does clozapine sit in FAERS report volume vs Atypical Antipsychotic peers? ▼
Registry note: FAERS counts are voluntary reports and do not establish causation or risk rates. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for clozapine: see also the generic vs brand label guide when reading Clozaril SPL strings.
Read our methodology - how this data is sourced, computed, and verified.