Theophylline and Progesterone Interaction
Drug interaction information between Theophylline and Progesterone.
Theophylline and Progesterone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Theophylline and Progesterone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
It is not fully known how progesterone affects theophylline, but it may change how quickly your body clears the drug. This could lead to theophylline levels being higher or lower than expected.
What To Do
Tell your doctor if you start or stop taking hormone therapy. They may need to check your blood levels to make sure your theophylline dose is still safe and effective.
FDA Label Information
The effect of progesterone on theophylline clearance is unknown. albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit...
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Progesterone Also Interacts With
- Isotretinoin major
- Amoxicillin minor
- Amoxicillin/Clavulanate minor
- Medroxyprogesterone minor
- Phenobarbital minor
Frequently Asked Questions
Can I take Theophylline and Progesterone together?
This is a major interaction. Tell your doctor if you start or stop taking hormone therapy. They may need to check your blood levels to make sure your theophylline dose is still safe and effective.
How serious is the interaction between Theophylline and Progesterone?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Theophylline and Progesterone interact?
It is not fully known how progesterone affects theophylline, but it may change how quickly your body clears the drug. This could lead to theophylline levels being higher or lower than expected.
Understanding the Theophylline and Progesterone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Theophylline belongs to the Methylxanthine Bronchodilator class and Progesterone belongs to the Progestogen Hormone class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: It is not fully known how progesterone affects theophylline, but it may change how quickly your body clears the drug. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Theophylline has 86 total documented interactions on file in this dataset, and Progesterone has 7. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Tell your doctor if you start or stop taking hormone therapy. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Theophylline or Progesterone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.