Theophylline and Progesterone Interaction

Drug interaction information between Theophylline and Progesterone.

Theophylline and Progesterone have a documented major interaction in FDA labeling.

FDA drug labeling documents a major-severity interaction between Theophylline and Progesterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Theophylline

Methylxanthine Bronchodilator

Drug B

Progesterone

Progestogen Hormone

How They Interact

It is not fully known how progesterone affects theophylline, but it may change how quickly your body clears the drug. This could lead to theophylline levels being higher or lower than expected.

FDA Label Information

The effect of progesterone on theophylline clearance is unknown. albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit...

Frequently Asked Questions

What SPL severity band is on file for Theophylline + Progesterone?

Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Theophylline has 86 labeled pairs on file vs Progesterone's 7. In the major band specifically: Theophylline has 27 (also Metoprolol, Albuterol, Omeprazole, Amoxicillin); Progesterone has 2 (also Isotretinoin).

What mechanism field is on file for Theophylline and Progesterone?

It is not fully known how progesterone affects theophylline, but it may change how quickly your body clears the drug. This could lead to theophylline levels being higher or lower than expected.

Theophylline carries more major-labeled pairs than Progesterone

SPL source-record counts only. This page's band is major · classes on file: Theophylline (Methylxanthine Bronchodilator); Progesterone (Progestogen Hormone).

Theophylline has 27 major-labeled pairs vs Progesterone's 2.

Theophylline

27 major · 5 moderate · 54 minor · 86 total

Progesterone

2 major · 0 moderate · 5 minor · 7 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.