Testosterone and Medroxyprogesterone Interaction
Drug interaction information between Testosterone and Medroxyprogesterone.
Testosterone and Medroxyprogesterone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Testosterone and Medroxyprogesterone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Medroxyprogesterone can lower the amount of testosterone found in your blood and urine.
What To Do
Your doctor may need to monitor your hormone levels or adjust your dosage if you take these together.
FDA Label Information
The following laboratory tests may be affected by progestins including medroxyprogesterone acetate injectable suspension: (a) Plasma and urinary steroid levels are decreased (e.g., progesterone, estradiol, pregnanediol, testosterone, cortisol).
Medroxyprogesterone Also Interacts With
- Theophylline major
- Estradiol minor
- Topiramate minor
- Progesterone minor
- Carbamazepine minor
Frequently Asked Questions
Can I take Testosterone and Medroxyprogesterone together?
This is a minor interaction. Your doctor may need to monitor your hormone levels or adjust your dosage if you take these together.
How serious is the interaction between Testosterone and Medroxyprogesterone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Testosterone and Medroxyprogesterone interact?
Medroxyprogesterone can lower the amount of testosterone found in your blood and urine.
Understanding the Testosterone and Medroxyprogesterone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Testosterone belongs to the Androgen Hormone class and Medroxyprogesterone belongs to the Progestogen class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Medroxyprogesterone can lower the amount of testosterone found in your blood and urine. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Testosterone has 2 total documented interactions on file in this dataset, and Medroxyprogesterone has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to monitor your hormone levels or adjust your dosage if you take these together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Testosterone or Medroxyprogesterone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.