Testosterone and Lovastatin Interaction
Drug interaction information between Testosterone and Lovastatin.
Testosterone and Lovastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Testosterone and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lovastatin does not significantly lower the amount of testosterone in your blood or stop your body from making it.
FDA Label Information
However, clinical studies have shown that lovastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve, and does not reduce basal plasma testosterone concentration. Another HMG-CoA reductase inhibitor has been shown to reduce the plasma testosterone response to HCG. In the same study, the mean testosterone response to HCG was slightly but not significantly reduced after treatment with lovastatin 40 mg daily for 16 weeks in 21 men.
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Testosterone + Lovastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lovastatin has 30 labeled pairs on file vs Testosterone's 2. In the minor band specifically: Testosterone has 2 (also Medroxyprogesterone); Lovastatin has 11 (also Glipizide, Propranolol, Warfarin, Digoxin).
What mechanism field is on file for Testosterone and Lovastatin?
Lovastatin does not significantly lower the amount of testosterone in your blood or stop your body from making it.
Lovastatin carries more major-labeled pairs than Testosterone
SPL source-record counts only. This page's band is minor · classes on file: Testosterone (Androgen Hormone); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Lovastatin has 2 major-labeled pairs vs Testosterone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Testosterone
- Medroxyprogesterone
2 major · 17 moderate · 11 minor · 30 total
- Other minor peers for Lovastatin
- Glipizide
- Propranolol
- Warfarin
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.