acebutolol vs tasimelteon
Side-by-side comparison of acebutolol and tasimelteon. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Recommendation: Your doctor may need to monitor your sleep patterns or adjust your medications if they are not working well.
Sectral
Hetlioz
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats. It belongs to a class of drugs called beta-blockers.
Tasimelteon (Hetlioz) is a medicine that helps people with Non-24-Hour Sleep-Wake Disorder (Non-24) sleep better. It works by acting like melatonin in your body.
Acebutolol is used to treat high blood pressure in adults. It can be used alone or with other blood pressure medicines. Acebutolol is also used to manage irregular heartbeats called ventricular arrhythmias. It helps to reduce the number of these irregular beats.
Tasimelteon is used to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where your body's natural sleep-wake cycle is longer than 24 hours. This medicine can help you sleep better at night.
Acebutolol works by blocking the effects of certain natural chemicals in your body, like adrenaline, on the heart and blood vessels. This helps to slow down the heart rate and lower blood pressure. It also helps to make the heart beat more regularly.
Tasimelteon is a melatonin receptor agonist. This means it works like melatonin, a natural hormone in your body that helps regulate sleep. By acting like melatonin, tasimelteon helps to adjust your body's sleep-wake cycle.
No common side effects listed.
- • Headache
- • Increased liver enzyme (alanine aminotransferase)
- • Nightmares or unusual dreams
- • Upper respiratory tract infection
- • Urinary tract infection
- Problems with thinking or memory 620
- Falling down 615
- Low blood pressure when standing up 573
- Problems with balance 568
- Difficulty passing stools 565
- Trouble falling asleep or staying asleep 727
- Waking up in the middle of the night 412
- Sleepiness 408
- Headache 384
- Nightmare 268
You should not take acebutolol if you have a very slow heart rate, second- or third-degree heart block, heart failure, or cardiogenic shock.
After taking tasimelteon, limit your activities to getting ready for bed. This medicine can make you sleepy and affect your ability to think clearly.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if acebutolol will harm an unborn baby. Talk to your doctor about the risks and benefits of taking acebutolol while breastfeeding.
There isn't enough information about using tasimelteon during pregnancy to know if it's safe. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if tasimelteon passes into breast milk, so discuss breastfeeding with your doctor.
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How to Read This acebutolol vs tasimelteon Comparison
acebutolol is classified in the Beta-1 Selective Blocker with ISA drug class, while tasimelteon sits within the Melatonin Receptor Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acebutolol has 2,941 submissions while tasimelteon has 2,199. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to acebutolol can lower the amount of natural melatonin your body makes. this may make tasimelteon less effective since it works on the same sleep system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between acebutolol and tasimelteon - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.