Retinol and Isotretinoin Interaction
Drug interaction information between Retinol and Isotretinoin.
Retinol and Isotretinoin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Retinol and Isotretinoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these are forms of Vitamin A, and taking them together can cause the vitamin to build up to toxic levels.
FDA Label Information
Drug Interactions Vitamin A: Because of the relationship of isotretinoin capsules to vitamin A, patients should be advised against taking vitamin supplements containing vitamin A to avoid additive toxic effects.
Isotretinoin Also Interacts With
- Progesterone major
- Estradiol minor
- Norethindrone minor
- Phenytoin minor
- Minocycline minor
Frequently Asked Questions
What SPL severity band is on file for Retinol + Isotretinoin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Isotretinoin has 7 labeled pairs on file vs Retinol's 3. In the moderate band specifically: Retinol has 2 (also Tretinoin); Isotretinoin has 1.
What mechanism field is on file for Retinol and Isotretinoin?
Both of these are forms of Vitamin A, and taking them together can cause the vitamin to build up to toxic levels.
Isotretinoin carries more major-labeled pairs than Retinol
SPL source-record counts only. This page's band is moderate · classes on file: Retinol (Vitamin A Supplement); Isotretinoin (Systemic Retinoid).
Isotretinoin has 1 major-labeled pair vs Retinol's 0. This page itself is in the moderate band, not the major band.
1 major · 1 moderate · 5 minor · 7 total
Isotretinoin has no other moderate-band peer in this dataset besides Retinol.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.