Retinol and Fluconazole Interaction
Drug interaction information between Retinol and Fluconazole.
Retinol and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Retinol and Fluconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Using these two together may lead to increased pressure inside the head, which can cause headaches and other brain-related side effects.
What To Do
Tell your doctor right away if you have a bad headache or changes in your vision while taking these medicines.
FDA Label Information
Vitamin A : Based on a case report in one patient receiving combination therapy with all-trans-retinoid acid (an acid form of vitamin A) and fluconazole, central nervous system (CNS) related undesirable effects have developed in the form of pseudotumor cerebri, which disappeared after discontinuation of fluconazole treatment.
Retinol Also Interacts With
- Isotretinoin moderate
- Tretinoin moderate
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
Can I take Retinol and Fluconazole together?
This is a minor interaction. Tell your doctor right away if you have a bad headache or changes in your vision while taking these medicines.
How serious is the interaction between Retinol and Fluconazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Retinol and Fluconazole interact?
Using these two together may lead to increased pressure inside the head, which can cause headaches and other brain-related side effects.
Understanding the Retinol and Fluconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Retinol belongs to the Vitamin A Supplement class and Fluconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Using these two together may lead to increased pressure inside the head, which can cause headaches and other brain-related side effects. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Retinol has 3 total documented interactions on file in this dataset, and Fluconazole has 67. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Tell your doctor right away if you have a bad headache or changes in your vision while taking these medicines. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Retinol or Fluconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.