Retinol and Fluconazole Interaction
Drug interaction information between Retinol and Fluconazole.
Retinol and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Retinol and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two together may lead to increased pressure inside the head, which can cause headaches and other brain-related side effects.
FDA Label Information
Vitamin A : Based on a case report in one patient receiving combination therapy with all-trans-retinoid acid (an acid form of vitamin A) and fluconazole, central nervous system (CNS) related undesirable effects have developed in the form of pseudotumor cerebri, which disappeared after discontinuation of fluconazole treatment.
Retinol Also Interacts With
- Isotretinoin moderate
- Tretinoin moderate
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Retinol + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Retinol's 3. In the minor band specifically: Retinol has 1; Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Retinol and Fluconazole?
Using these two together may lead to increased pressure inside the head, which can cause headaches and other brain-related side effects.
Fluconazole carries more major-labeled pairs than Retinol
SPL source-record counts only. This page's band is minor · classes on file: Retinol (Vitamin A Supplement); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Retinol's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 1 minor · 3 total
Retinol has no other minor-band peer in this dataset besides Fluconazole.
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.