What the FDA labels say about taking them together
Amiodarone and propafenone
Propafenone's FDA label of September 1, 2025 names amiodarone in its drug interactions section; the amiodarone labels PlainMeds reads (2) do not name propafenone. The propafenone label: “Avoid the use of propafenone with Class IA and III antiarrhythmic agents.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the amiodarone label say about propafenone?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name propafenone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the propafenone label say about amiodarone?
Propafenone label, drug interactionsConcomitant administration of propafenone and amiodarone can affect conduction and repolarization and is not recommended.
Propafenone label, warnings and precautionsAvoid the use of propafenone with Class IA and III antiarrhythmic agents (including quinidine and amiodarone).
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Propafenone | |
|---|---|---|
| Labeled for | n/a | Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.115 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once