Propafenone and Amiodarone Interaction
Drug interaction information between Propafenone and Amiodarone.
Propafenone and Amiodarone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Propafenone and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two heart medicines together can change how electrical signals travel through your heart. This can interfere with your heart's rhythm and how it resets between beats.
FDA Label Information
Amiodarone Concomitant administration of propafenone and amiodarone can affect conduction and repolarization and is not recommended.
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
- Erythromycin minor
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Propafenone + Amiodarone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Propafenone's 26. In the moderate band specifically: Propafenone has 3 (also Fluoxetine, Nebivolol); Amiodarone has 9 (also Lithium, Clarithromycin, Fluconazole, Ledipasvir/Sofosbuvir).
What mechanism field is on file for Propafenone and Amiodarone?
Taking these two heart medicines together can change how electrical signals travel through your heart. This can interfere with your heart's rhythm and how it resets between beats.
Amiodarone carries more major-labeled pairs than Propafenone
SPL source-record counts only. This page's band is moderate · classes on file: Propafenone (Class IC Antiarrhythmic); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Propafenone's 1. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 22 minor · 26 total
- Other moderate peers for Propafenone
- Fluoxetine
- Nebivolol
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Lithium
- Clarithromycin
- Fluconazole
- Ledipasvir/Sofosbuvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.