Propafenone and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Propafenone and Nirmatrelvir/Ritonavir.
Propafenone and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Propafenone and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these together causes propafenone to stay in your body longer and reach higher levels than intended. This can lead to serious and potentially fatal heart rhythm disturbances.
FDA Label Information
Antiarrhythmics amiodarone, dronedarone, flecainide, propafenone, quinidine ↑ antiarrhythmic Co-administration contraindicated due to potential for cardiac arrhythmias [see Contraindications (4) ] .
Propafenone Also Interacts With
- Amiodarone moderate
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
- Erythromycin minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Propafenone + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Propafenone's 26. In the major band specifically: Propafenone has 1; Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Propafenone and Nirmatrelvir/Ritonavir?
Taking these together causes propafenone to stay in your body longer and reach higher levels than intended. This can lead to serious and potentially fatal heart rhythm disturbances.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Propafenone
SPL source-record counts only. This page's band is major · classes on file: Propafenone (Class IC Antiarrhythmic); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Propafenone's 1.
1 major · 3 moderate · 22 minor · 26 total
Propafenone has no other major-band peer in this dataset besides Nirmatrelvir/Ritonavir.
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.