Pioglitazone · more major-labeled pairs than Metformin/Pioglitazone
SPL labels Pioglitazone + Metformin/Pioglitazone as minor; Pioglitazone 9 / Metformin/Pioglitazone 7 in that band.
Mechanism on file: Other medications can change how your body processes pioglitazone, leading to levels that are either too high or too low.
FDA SPL severity: Minor
Pioglitazone + Metformin/Pioglitazone · SPL mechanism field
Other medications can change how your body processes pioglitazone, leading to levels that are either too high or too low.
Minor band excerpt · Pioglitazone with Metformin/Pioglitazone
( 7.1 ) CYP2C8 inducers (e.g., rifampin) may decrease pioglitazone concentrations. ( 7.6 ) Topiramate may decrease pioglitazone concentrations. ( 7.8 ) 7.1 Strong CYP2C8 Inhibitors An inhibitor of CYP2C8 (e.g., gemfibrozil) significantly increases the exposure (area under the serum concentration-time curve or AUC) and half-life (t ½ ) of pioglitazone.
Pioglitazone · 1 major-labeled pairs (vs Metformin/Pioglitazone's 0)
- Abiraterone minor
- Dapagliflozin minor
- Gemfibrozil minor
- Leflunomide minor
Metformin/Pioglitazone · 7 minor + 10 total pairs
- Gemfibrozil minor
- Metformin minor
- Phenytoin minor
- Rifampin minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.