Phenytoin · more major-labeled pairs than Acetaminophen/Oxycodone
SPL labels Phenytoin + Acetaminophen/Oxycodone as minor; Phenytoin 120 / Acetaminophen/Oxycodone 21 in that band.
Mechanism on file: Phenytoin speeds up how your body breaks down oxycodone, which can lower the amount of medicine in your blood.
FDA SPL severity: Minor
Phenytoin + Acetaminophen/Oxycodone · SPL mechanism field
Phenytoin speeds up how your body breaks down oxycodone, which can lower the amount of medicine in your blood.
Minor band excerpt · Phenytoin with Acetaminophen/Oxycodone
Inducers of CYP3A4 The concomitant use of PERCOCET and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY ] , resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to PERCOCET [see WARNINGS ] .
Phenytoin · 4 major-labeled pairs (vs Acetaminophen/Oxycodone's 0)
- Acarbose minor
- Albendazole minor
- Alogliptin minor
- Alprazolam minor
Acetaminophen/Oxycodone · 21 minor + 23 total pairs
- Acetaminophen minor
- Butorphanol minor
- Carbamazepine minor
- Cyclobenzaprine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.